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1. WO2010146604 - PROCESSES FOR PREPARING METFORMIN HYDROCHLORIDE

Publication Number WO/2010/146604
Publication Date 23.12.2010
International Application No. PCT/IN2010/000417
International Filing Date 17.06.2010
Chapter 2 Demand Filed 03.01.2011
IPC
C07C 277/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
277Preparation of guanidine or its derivatives, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
02of guanidine from cyanamide, calcium cyanamide or dicyandiamides
C07C 277/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
277Preparation of guanidine or its derivatives, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
08of substituted guanidines
C07C 279/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
20containing any of the groups X being a hetero atom, Y being any atom, e.g. acylguanidines
24Y being a hetero atom
26X and Y being nitrogen atoms, i.e. biguanides
A61K 31/155 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
155Amidines , e.g. guanidine , isourea , isothiourea
CPC
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
C07C 277/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
277Preparation of guanidine or its derivatives, i.e. compounds containing the group , the singly-bound nitrogen atoms not being part of nitro or nitroso groups
02of guanidine from cyanamide, calcium cyanamide or dicyandiamides
C07C 277/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
277Preparation of guanidine or its derivatives, i.e. compounds containing the group , the singly-bound nitrogen atoms not being part of nitro or nitroso groups
08of substituted guanidines
C07C 279/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group , the singly-bound nitrogen atoms not being part of nitro or nitroso groups
20containing any of the groups , X being a hetero atom, Y being any atom, e.g. acylguanidines
24Y being a hetero atom
26X and Y being nitrogen atoms, i.e. biguanides
Applicants
  • PATEL, PRANAV DUSHYANT AND PATEL, SHIVANI PRANAV TRADING AS EXEMED PHARMACEUTICALS, A PARTNERSHIP FIRM [IN]/[IN] (AllExceptUS)
  • PATEL, Pranav, Dushyant [IN]/[IN] (UsOnly)
  • PATEL, Dinesh, Ramanlal [IN]/[IN] (UsOnly)
Inventors
  • PATEL, Pranav, Dushyant
  • PATEL, Dinesh, Ramanlal
Agents
  • SUBRAMANIAM, Hariharan
Priority Data
1459/MUM/200918.06.2009IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESSES FOR PREPARING METFORMIN HYDROCHLORIDE
(FR) PROCÉDÉS DE PRÉPARATION DE CHLORHYDRATE DE METFORMINE
Abstract
(EN) A process for reducing dimethylamine content in metformin hydrochloride is disclosed. The process comprises: (a) providing metformin hydrochloride having dimethylamine content more than 15 ppm; (b) pulverizing the metformin hydrochloride; (c) slurrying the metformin hydrochloride in one or more Cj-C4 alcohol solvents; and (d) isolating the metformin hydrochloride.
(FR) L'invention concerne un procédé de réduction de la teneur en diméthylamine de chlorhydrate de metformine, consistant (a) à fournir du chlorhydrate de metformine ayant une teneur en diméthylamine supérieure à 15 ppm; (b) à pulvériser le chlorhydrate de metformine; (c) à mettre en suspension le chlorhydrate de metformine dans un ou plusieurs solvants C1-C4-alcool; et (d) à isoler le chlorhydrate de metformine.
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