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Pub. No.:    WO/2010/146550    International Application No.:    PCT/IB2010/052711
Publication Date: 23.12.2010 International Filing Date: 16.06.2010
C07K 16/28 (2006.01), C07K 16/32 (2006.01)
Applicants: PFIZER INC. [US/US]; 235 East 42nd Street New York, NY 10017 (US) (For All Designated States Except US).
RINAT NEUROSCIENCE CORPORATION [US/US]; 230 East Grand Avenue South San Francisco, CA 94080 (US) (For All Designated States Except US).
HOSTOMSKY, Zdenek [US/US]; (US) (For US Only).
LI, Kang [US/US]; (US) (For US Only).
LIPPINCOTT, John, Andrew [US/US]; (US) (For US Only).
PENG, Qinghai [US/US]; (US) (For US Only).
STONE, Donna, Marie [US/US]; (US) (For US Only).
WEI, Ping [US/US]; (US) (For US Only)
Inventors: HOSTOMSKY, Zdenek; (US).
LI, Kang; (US).
LIPPINCOTT, John, Andrew; (US).
PENG, Qinghai; (US).
STONE, Donna, Marie; (US).
WEI, Ping; (US)
Agent: BENSON, Gregg C.; Pfizer Inc. Eastern Point Road MS9114 Groton, CT 06340 (US)
Priority Data:
61/218,193 18.06.2009 US
Abstract: front page image
(EN)This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.
(FR)L'invention concerne des anticorps monoclonaux qui se lient spécifiquement à Notch1. Dans un mode de réalisation, les anticorps se lient à au moins un premier épitope et un deuxième épitope, le premier épitope étant contenu dans domaine LinA de la zone de régulation négative (NRR) de Notch1 et le deuxième épitope étant contenu dans le domaine HD-C de la NRR de Notch1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)