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1. (WO2010146299) AZETIDINE-DERIVED ESTERS, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS CANNABINOID RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/146299    International Application No.:    PCT/FR2010/051187
Publication Date: 23.12.2010 International Filing Date: 15.06.2010
IPC:
C07D 205/02 (2006.01), C07D 405/12 (2006.01), C07D 295/092 (2006.01), A61K 31/397 (2006.01), A61K 31/5377 (2006.01), A61P 3/00 (2006.01), A61P 5/00 (2006.01), A61P 1/00 (2006.01), A61P 9/00 (2006.01), A61P 13/00 (2006.01), A61P 19/00 (2006.01), A61P 25/00 (2006.01), A61P 27/00 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: SANOFI [FR/FR]; 174 avenue de France F-75013 Paris (FR) (For All Designated States Except US).
GEORGE, Pascal [BE/FR]; (FR) (For US Only).
SABUCO, Jean-François [FR/FR]; (FR) (For US Only)
Inventors: GEORGE, Pascal; (FR).
SABUCO, Jean-François; (FR)
Agent: MOREL-PECHEUX, Muriel; c/o sanofi-aventis Département Brevets 174 avenue de France F-75013 Paris (FR)
Priority Data:
0954039 16.06.2009 FR
Title (EN) AZETIDINE-DERIVED ESTERS, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS CANNABINOID RECEPTOR MODULATORS
(FR) ESTERS DERIVES D'AZETIDINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE COMME MODULATEURS DES RECEPTEURS CANNABINOIDES
Abstract: front page image
(EN)The invention relates to the compounds of formula (I), where: R is a (C1-C6)alkyl or halo(C1-C6)alkyl group; A is a carbon atom optionally substituted by one or more hydrogen atoms or (C1-C6)alkyl groups; R5 is one or two carbon atoms substituted by one or more groups selected from among the hydroxy, (C1-C6)alkoxy, OCOR2, OCOOR6, or NRaRb groups or a heterocyclic group optionally substituted by a halogen atom or a (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, or oxo group; R1 is a hydrogen atom or a (C1-C6)alkyl group; R2 is a hydrogen atom or a (C1-C6)alkyl group; each of R3 and R4 is a phenyl group optionally substituted by one or more atoms or groups selected from among a hydrogen atom, a halogen atom, a (C1-C6)alkyl group, a (C1-C6)alkoxy group, a halo(C1-C6)alkoxy group, or a cyano group; R6 is a (C1-C6)alkyl group; Ra and Rb are, independently of each other, a hydrogen atom or a (C1-C6)alkyl group; Y is a hydrogen atom, a halogen, a (C1-C6)alkyl group, a halo(C1-C6)alkyl group, a (C1-C6)alkoxy group, a halo(C1-C6)alkoxy group, a (C1-C6)alkylS(0)p group, or a cyano group; and p is between 0 and 2 in the state of a base or of an acid addition salt. The invention also relates to a method for preparing same to the therapeutic use thereof.
(FR)Composés répondant à la formule (I) et leur procédé de préparation et application en thérapeutique comme modulateurs des récepteurs des cannabinoides CB1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)