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1. (WO2010146172) NEW SYNTHETIC ROUTE FOR THE PREPARATION OF ALPHA-AMINO BORONIC ESTERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/146172    International Application No.:    PCT/EP2010/058666
Publication Date: 23.12.2010 International Filing Date: 18.06.2010
IPC:
C07F 5/02 (2006.01), C07F 17/00 (2006.01), C07K 5/06 (2006.01), C07C 209/68 (2006.01), C07F 5/06 (2006.01)
Applicants: LEK PHARMACEUTICALS D.D. [SI/SI]; Verovskova 57 1526 Ljubljana (SI) (For All Designated States Except US).
GAZIC SMILOVIC, Ivana [SI/SI]; (SI) (For US Only).
CASAR, Zdenko [SI/SI]; (SI) (For US Only)
Inventors: GAZIC SMILOVIC, Ivana; (SI).
CASAR, Zdenko; (SI)
Agent: KUNIC-TESOVIC, Barbara; Verovskova 57 1526 Ljubljana (SI)
Priority Data:
09163227.3 19.06.2009 EP
09166475.5 27.07.2009 EP
09180099.5 21.12.2009 EP
Title (EN) NEW SYNTHETIC ROUTE FOR THE PREPARATION OF ALPHA-AMINO BORONIC ESTERS
(FR) NOUVELLE TECHNIQUE DE SYNTHÈSE POUR LA PRÉPARATION DE DÉRIVÉS D'ACIDE α-AMINOBORONIQUE PAR L'INTERMÉDIAIRE D'ALK-1-YNES SUBSTITUÉES
Abstract: front page image
(EN)The present invention relates in general to the field of organic chemistry and in particular to the preparation of alpha-amino boronic esters. These compounds can be used as intermediates in the synthesis of boronic acid and ester compounds such as N- terminal peptidyl boronic acid derivatives, for example N-(pyrazin-2-yl)carbonyl-L-phenylalanine-L-leucine boronic acid, i.e. bortezomib.
(FR)La présente invention concerne généralement le domaine de la chimie organique et plus particulièrement la préparation de dérivés d'acide α-aminoboronique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)