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236. (WO2010146132) SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS

Pub. No.:    WO/2010/146132    International Application No.:    PCT/EP2010/058573
Publication Date: Fri Dec 24 00:59:59 CET 2010 International Filing Date: Fri Jun 18 01:59:59 CEST 2010
IPC: C07D 239/48
C07D 403/12
C07D 403/14
A61K 31/506
A61P 37/00
Applicants: CELLZOME LIMITED
MAJOR, Jeremy
PITON, Nelly
Inventors: MAJOR, Jeremy
PITON, Nelly
Title: SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS
Abstract:
The invention relates to compounds of formula (I), wherein R1 to R6 and T0 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.