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Pub. No.:    WO/2010/144740    International Application No.:    PCT/US2010/038224
Publication Date: 16.12.2010 International Filing Date: 10.06.2010
A61K 9/127 (2006.01), C07C 211/00 (2006.01), A61K 31/20 (2006.01)
Applicants: ALNYLAM PHARMACEUTICALS, INC. [US/US]; 300 Third Street Cambridge, MA 02142 (US) (For All Designated States Except US).
CHEN, Jianxin [CA/--]; (US) (For US Only).
ANSELL, Steven [CA/--]; (US) (For US Only).
AKINC, Akin [US/US]; (US).
DORKIN, Joseph, R. [US/US]; (US).
QIN, Xiaojun [US/--]; (US).
CANTLEY, William [US/--]; (GB).
MANOHARAN, Muthiah [US/US]; (US).
RAJEEV, Kallanthottathil, G. [IN/US]; (US).
NARAYANANNAIR, Jayaprakash, K. [IN/--]; (US).
JAYARAMAN, Muthusamy [IN/US]; (US)
Inventors: CHEN, Jianxin; (US).
ANSELL, Steven; (US).
AKINC, Akin; (US).
DORKIN, Joseph, R.; (US).
QIN, Xiaojun; (US).
CANTLEY, William; (GB).
MANOHARAN, Muthiah; (US).
RAJEEV, Kallanthottathil, G.; (US).
NARAYANANNAIR, Jayaprakash, K.; (US).
JAYARAMAN, Muthusamy; (US)
Agent: MCCARTY, Cathy, M.; Lando & Anastasi Llp Riverfront Office Park One Main Street, Suite 1100 Cambridge, MA 02142 (US)
Priority Data:
61/185,800 10.06.2009 US
61/244,834 22.09.2009 US
Abstract: front page image
(EN)The invention features a cationic lipid of formula (I), an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.
(FR)L'invention porte sur un lipide cationique de formule (I), sur une formulation lipidique améliorée comprenant un lipide cationique de formule (I) et sur des procédés d'utilisation correspondants. L'invention porte également sur des lipides de ciblage, et sur des formulations lipidiques spécifiques comprenant de tels lipides de ciblage.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)