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1. (WO2010144698) METHODS, SYSTEMS, AND COMPOSITIONS FOR NEURONAL DIFFERENTIATION OF MULTIPOTENT STROMAL CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/144698 International Application No.: PCT/US2010/038168
Publication Date: 16.12.2010 International Filing Date: 10.06.2010
IPC:
C12N 15/11 (2006.01) ,C07H 21/04 (2006.01) ,C12N 5/00 (2006.01) ,C12N 5/071 (2010.01)
Applicants: BRODIE, Chaya[US/US]; US (UsOnly)
SLAVIN, Shimon[US/IL]; IL
Inventors: BRODIE, Chaya; US
SLAVIN, Shimon; IL
Agent: MOYNIHAN, Martin, D.; PRTSI, INC. P.O.Box 16446 Arlington, Virginia 22215, US
Priority Data:
61/185,77310.06.2009US
Title (EN) METHODS, SYSTEMS, AND COMPOSITIONS FOR NEURONAL DIFFERENTIATION OF MULTIPOTENT STROMAL CELLS
(FR) PROCÉDÉS, SYSTÈMES ET COMPOSITIONS POUR LA DIFFÉRENTIATION NEURONALE DE CELLULES STROMALES PLURIPOTENTES
Abstract: front page image
(EN) Some embodiments of the invention comprise methods, systems, and compositions to selectively induce, whether in vitro or in vivo, the neuronal differentiation of multipotent stromal cells through the application of microRNAs, including but not limited to miRNA- 124, miRNA-137 and/or miRNA-9* expression products of those miRNAs, and molecules and compositions containing functional elements of those miRNAs. Some embodiments of the invention also comprise the therapeutic administration and use of such induced cells to treat mammalian injuries and diseases, including but not limited to, nervous system injuries or diseases that may otherwise result in decreased cell or system function.
(FR) Certains modes de réalisation de l'invention comprennent des procédés, des systèmes et des compositions pour induire de manière sélective, que ce soit in vitro ou in vivo, la différentiation neuronale de cellules stromales multipotentes par l'application de micro-ARN, comprenant mais sans y être limités miARN-124, miARN-137 et/ou miARN-9*, des produits d'expression de ces miARN, et des molécules et des compositions contenant des éléments fonctionnels de ces miARN. Certains modes de réalisation de l'invention comprennent également l'administration thérapeutique et l'utilisation de telles cellules induites pour traiter des lésions et maladies de mammifère, comprenant mais sans y être limitées, des lésions ou maladies du système nerveux qui peuvent sinon conduire à une fonction cellulaire ou systémique diminuée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)