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1. (WO2010144679) BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/144679    International Application No.:    PCT/US2010/038135
Publication Date: 16.12.2010 International Filing Date: 10.06.2010
IPC:
A61P 25/00 (2006.01), A61K 31/4184 (2006.01), A61K 31/4188 (2006.01), C07D 235/30 (2006.01), C07D 498/06 (2006.01)
Applicants: JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30 B-2340 Beerse (BE) (For All Designated States Except US).
MACIELAG, Mark, J. [US/US]; (US) (For US Only).
XIA, Mingde [US/US]; (US) (For US Only).
XU, Xiaoqing [US/US]; (US) (For US Only)
Inventors: MACIELAG, Mark, J.; (US).
XIA, Mingde; (US).
XU, Xiaoqing; (US)
Agent: JOHNSON, Philip, S.; JOHNSON & JOHNSON 1 Johnson & Johnson Plaza New Brunswick, NJ 08933 (US)
Priority Data:
61/185,681 10.06.2009 US
Title (EN) BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS
(FR) DÉRIVÉS DE BENZIMIDAZOLE UTILES COMME MODULATEURS DU CANAL TRMP8
Abstract: front page image
(EN)Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows wherein R0, R1, R2, R3, R4 and a are defined herein. The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the TRPM8 (transient receptor potential melastatin subfamily type 8) channel. The present invention also relates to processes for the preparation of benzimidazole derivatives and to their use in treating various diseases, syndromes, and disorders, including, those that cause inflammatory pain, neuropathic pain, cardiovascular diseases aggravated by cold, pulmonary diseases aggravated by cold, and combinations thereof.
(FR)L'invention concerne des composés, des compositions et des méthodes de traitement de diverses maladies, syndromes, états pathologiques et troubles, y compris la douleur. Ces composés sont représentés par la formule (I) suivante, dans laquelle R0, R1, R2, R3, R4 et a sont définis dans la demande. L'invention concerne directement des dérivés de benzimidazole, des compositions pharmaceutiques contenant ceux-ci ainsi que leur utilisation dans le traitement de troubles et d'états pathologiques modulés par le canal TRPM8 (sous-famille TRP mélastatine de type 8). L'invention concerne aussi un procédé de préparation de dérivés de benzimidazole et leur utilisation dans le traitement de diverses maladies et divers syndromes et troubles comprenant celles/ceux causant des douleurs inflammatoires, des douleurs neuropathiques, des maladies cardiovasculaires aggravées par le froid, des maladies pulmonaires aggravées par le froid et des combinaisons de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)