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1. (WO2010144586) ISOQUINOLINE, QUINOLINE, AND QUINAZOLINE DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/144586    International Application No.:    PCT/US2010/037986
Publication Date: 16.12.2010 International Filing Date: 09.06.2010
IPC:
A01N 43/42 (2006.01), A61K 31/47 (2006.01), A61K 31/517 (2006.01)
Applicants: ABRAXIS BIOSCIENCE, LLC [US/US]; 11755 Wilshire Boulevard, Suite 2000 Los Angeles, California 90025 (US) (For All Designated States Except US).
TAO, Chunlin [US/US]; (US) (For US Only).
SUN, Xiaowen [CN/US]; (US) (For US Only).
HAN, Hongna [CN/US]; (US) (For US Only).
KORONIAK, Lukasz [PL/PL]; (PL) (For US Only).
DESAI, Neil [US/US]; (US) (For US Only)
Inventors: TAO, Chunlin; (US).
SUN, Xiaowen; (US).
HAN, Hongna; (US).
KORONIAK, Lukasz; (PL).
DESAI, Neil; (US)
Agent: DOMER, Peter H.; Leydig, Voit & Mayer, LTD. Two Prudential Plaza, Suite 4900 Chicago, Illinois 60601 (US)
Priority Data:
61/185,412 09.06.2009 US
Title (EN) ISOQUINOLINE, QUINOLINE, AND QUINAZOLINE DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING
(FR) DÉRIVÉS DE L'ISOQUINOLÉINE, DE LA QUINOLÉINE ET DE LA QUINAZOLÉINE SERVANT D'INHIBITEURS DE SIGNAL HEDGEHOG
Abstract: front page image
(EN)The invention provides isoquinoline, quinoline, and quinazoline derivatives to treat a variety of disorders, diseases and pathologic conditions, and more specifically to the use of isoquinoline, quinoline, and quinazoline derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds to the treatment of hyperproliferative diseases and pathologic angiogenesis.
(FR)L'invention porte sur des dérivés de l'isoquinoléine, de la quinoléine et de la quinazoléine pour traiter une variété de troubles, de maladies et d'états pathologiques et, plus précisément, sur l'utilisation de dérivés de l'isoquinoléine, de la quinoléine et de la quinazoléine pour inhiber le trajet de signal Hedgehog, et sur l'utilisation de ces composés dans le traitement de maladies hyper prolifératives et de l'angiogenèse pathologique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)