WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2010144571) HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/144571    International Application No.:    PCT/US2010/037964
Publication Date: 16.12.2010 International Filing Date: 09.06.2010
IPC:
C07D 491/10 (2006.01), C07D 491/20 (2006.01), A61K 31/438 (2006.01), A61P 3/00 (2006.01), A61P 25/04 (2006.01), A61P 25/08 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01), A61P 25/28 (2006.01)
Applicants: Sunovion Pharmaceuticals Inc. [US/US]; 84 Waterford Drive Marlborough, MA 01752 (US) (For All Designated States Except US).
CHYTIL, Milan [US/US]; (US) (For US Only).
ENGEL, Sharon, R. [US/US]; (US) (For US Only).
FANG, Qun, Kevin [US/US]; (US) (For US Only)
Inventors: CHYTIL, Milan; (US).
ENGEL, Sharon, R.; (US).
FANG, Qun, Kevin; (US)
Agent: INSOGNA, Anthony M.; Jones Day 222 East 41st Street New York, NY 10017-6702 (US)
Priority Data:
61/185,936 10.06.2009 US
Title (EN) HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF
(FR) AGONISTES INVERSES ET ANTAGONISTES DE L'HISTAMINE H3 ET MÉTHODES D'UTILISATION ASSOCIÉES
Abstract: front page image
(EN)Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.
(FR)La présente invention concerne des composés spiro-cycliques, des méthodes de synthèse, et des méthodes d'utilisation associées. Les composés proposés ici sont utiles pour le traitement, la prévention, et/ou la prise en charge de divers troubles, notamment par exemple les troubles neurologiques et les troubles métaboliques. Les composés proposés ici inhibent l'activité des récepteurs de l'histamine de type H3 et modulent la libération de divers neurotransmetteurs, tels que par exemple l'histamine, l'acétylcholine, la norépinéphrine, et la dopamine (par exemple au niveau de la synapse). L'invention concerne également des compositions pharmaceutiques contenant les composés et leurs méthodes d'utilisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)