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1. (WO2010144358) HIGHLY SENSITIVE BIOMARKER PANELS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/144358    International Application No.:    PCT/US2010/037613
Publication Date: 16.12.2010 International Filing Date: 07.06.2010
IPC:
G01N 33/68 (2006.01), G01N 33/52 (2006.01)
Applicants: SINGULEX, INC. [US/US]; 1650 Harbor Bay Parkway, Suite 200 Alameda, CA 94502-3012 (US) (For All Designated States Except US).
GOIX, Philippe, J. [US/US]; (US) (For US Only).
PUSKAS, Robert [US/US]; (US) (For US Only).
TODD, John [US/US]; (US) (For US Only).
LIVINGSTON, Richard [US/US]; (US) (For US Only).
HELD, Douglas [US/US]; (US) (For US Only).
LE, Sara [US/US]; (US) (For US Only)
Inventors: GOIX, Philippe, J.; (US).
PUSKAS, Robert; (US).
TODD, John; (US).
LIVINGSTON, Richard; (US).
HELD, Douglas; (US).
LE, Sara; (US)
Agent: GATTARI, Patrick, G.; McDonnell Boehnen Hulbert & Berghoff LLP 300 South Wacker Drive, Suite 3100 Chicago, IL 60606 (US)
Priority Data:
61/185,194 08.06.2009 US
Title (EN) HIGHLY SENSITIVE BIOMARKER PANELS
(FR) GROUPES DE BIOMARQUEURS TRÈS SENSIBLES
Abstract: front page image
(EN)Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnl, BNP) and vascular inflammation (IL-6, TNFα, IL- 17a) biomarkers provided a sensitivity of 94% for association with CHF.
(FR)Une maladie cardio-vasculaire, par exemple une insuffisance cardiaque congestive, est souvent diagnostiquée pour la première fois après le début des symptômes cliniques, ce qui élimine la possibilité d'une intervention précoce. L'invention concerne un immuno-essai utilisant plusieurs marqueurs, notamment des biomarqueurs de pathologie cardiaque et d'inflammation vasculaire. Cet immuno-essai plus sensible permet la détection précoce d'une insuffisance cardiaque congestive (CHF) grâce à l'analyse du plasma. Un groupe constitué de biomarqueurs de pathologie cardiaque (cTnl, BNP) et d'inflammation vasculaire (IL-6, TNFα, IL-17a) procure une sensibilité de 94 % en liaison avec une insuffisance cardiaque congestive (CHF).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)