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1. (WO2010144293) SYNTHESIS OF TELCAGEPANT AND INTERMEDIATES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/144293    International Application No.:    PCT/US2010/037148
Publication Date: 16.12.2010 International Filing Date: 03.06.2010
IPC:
C07D 401/00 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
XU, Feng [CN/US]; (US) (For US Only).
DESMOND, Richard [US/US]; (US) (For US Only).
HOERRNER, R. Scott [US/US]; (US) (For US Only).
HUMPHREY, Guy, R. [GB/US]; (US) (For US Only).
ITOH, Tetsuji [JP/US]; (US) (For US Only).
JOURNET, Michel [FR/US]; (US) (For US Only).
YOSHIKAWA, Naoki [JP/US]; (US) (For US Only).
ZACUTO, Michael, J. [US/US]; (US) (For US Only)
Inventors: XU, Feng; (US).
DESMOND, Richard; (US).
HOERRNER, R. Scott; (US).
HUMPHREY, Guy, R.; (US).
ITOH, Tetsuji; (US).
JOURNET, Michel; (US).
YOSHIKAWA, Naoki; (US).
ZACUTO, Michael, J.; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
61/185,070 08.06.2009 US
Title (EN) SYNTHESIS OF TELCAGEPANT AND INTERMEDIATES THEREOF
(FR) SYNTHÈSE DE TELCAGÉPANT ET INTERMÉDIAIRES DE CELUI-CI
Abstract: front page image
(EN)Disclosed is an efficient synthesis for the manufacture of the caprolactam intermediate (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one: Formula and salts thereof, and an efficient preparation of telcagepant using the caprolactam intermediate.
(FR)La présente invention concerne une synthèse efficace pour la fabrication de l'intermédiaire caprolactame (3R,6S)-3-amino-6-(2,3-difluorophényl)-1-(2,2,2-trifluoroéthyl)azépan-2-one : Formule et des sels de celui-ci, et une préparation efficace de telcagépant utilisant l'intermédiaire caprolactame.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)