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1. (WO2010143074) PHARMACEUTICAL DOSAGE FORM FOR ORAL ADMINISTRATION OF A BCL-2 FAMILY INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/143074    International Application No.:    PCT/IB2010/001659
Publication Date: 16.12.2010 International Filing Date: 08.06.2010
IPC:
A61K 9/00 (2006.01), A61K 31/5377 (2006.01), A61K 9/14 (2006.01)
Applicants: ABBOTT GMBH & CO. KG [DE/DE]; Max-planck-ring 2 65205 Wiesbaden (DE) (For All Designated States Except US).
PACKHAEUSER, Claudia [DE/DE]; (DE) (For US Only).
STEIGER, Norbert [DE/DE]; (DE) (For US Only).
LIEPOLD, Bernd [DE/DE]; (DE) (For US Only).
KOSTELAC, Drazen [DE/DE]; (DE) (For US Only).
KNOBLOCH, Martin [DE/DE]; (DE) (For US Only)
Inventors: PACKHAEUSER, Claudia; (DE).
STEIGER, Norbert; (DE).
LIEPOLD, Bernd; (DE).
KOSTELAC, Drazen; (DE).
KNOBLOCH, Martin; (DE)
Agent: MODIANO & PARTNERS; Thierschstrasse, 11 80538 Münich (IT)
Priority Data:
61/185,130 08.06.2009 US
Title (EN) PHARMACEUTICAL DOSAGE FORM FOR ORAL ADMINISTRATION OF A BCL-2 FAMILY INHIBITOR
(FR) FORME POSOLOGIQUE PHARMACEUTIQUE POUR L'ADMINISTRATION ORALE D'UN INHIBITEUR DE LA FAMILLE DE BCL-2
Abstract: front page image
(EN)The invention relates to a pharmaceutical dosage form which comprises a solid dispersion product comprising N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-l-cyclohex-l-en- 1-yl)methyl)piperazin- 1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1- ((phenylsulfanyl)methyl) propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide or a salt, hydrate or solvate thereof, at least one pharmaceutically acceptable polymer, and at least one pharmaceutically acceptable solubilizer. The invention is further directed to processes for preparing the pharmaceutical dosage form and to use of the dosage form for treating proliferative disorders.
(FR)L'invention porte sur une forme posologique pharmaceutique qui comprend un produit de dispersion solide comprenant du N-(4-(4-((2-(4-chlorophényl)-5,5-diméthyl-l-cyclohex-l-én-1-yl)méthyl)pipérazin-1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1-((phénylsulfanyl)méthyl) propyl)amino)-3-((trifluorométhyl)sulfonyl)benzènesulfonamide ou un sel, un hydrate ou un solvate de celui-ci, au moins un polymère pharmaceutiquement acceptable et au moins un solubilisant pharmaceutiquement acceptable. L'invention porte également sur des procédés de préparation de la forme posologique pharmaceutique et sur l'utilisation de la forme posologique pour le traitement de troubles de la prolifération.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)