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1. (WO2010142952) ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/142952    International Application No.:    PCT/GB2010/001130
Publication Date: 16.12.2010 International Filing Date: 09.06.2010
C07K 16/28 (2006.01)
Applicants: AFFITECH RESEARCH AS [NO/NO]; Oslo Research Park Gaustadalléen 21 N-0349 Oslo (NO) (For All Designated States Except US).
CICORTAS GUNNARSSON, Lavinia Diana [SE/NO]; (NO) (For US Only).
PAUS, Didrik [NO/NO]; (NO) (For US Only).
RIGBY, Barbara [DE/GB]; (GB) (BB only)
Inventors: CICORTAS GUNNARSSON, Lavinia Diana; (NO).
PAUS, Didrik; (NO)
Agent: DEHNS; St. Bride's House 10 Salisbury Square London EC4Y 8JD (GB)
Priority Data:
0909906.0 09.06.2009 GB
61/185,448 09.06.2009 US
61/302,768 09.02.2010 US
Abstract: front page image
(EN)The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields.
(FR)La présente invention concerne des anticorps qui se lient à un épitope dans le domaine extracellulaire du récepteur aux chimiokines CC de type 4 humain (CCR4) et qui peuvent inhiber la liaison de la chimiokine dérivée des macrophages (MDC) et/ou de la chimiokine régulée par le thymus et activation au CCR4. L'invention concerne également entre autres des immunoconjugués et des compositions comprenant lesdits anticorps et des procédés et utilisations impliquant lesdits anticorps, particulièrement dans les domaines médical et diagnostique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)