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1. (WO2010142801) INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/142801    International Application No.:    PCT/EP2010/058271
Publication Date: 16.12.2010 International Filing Date: 11.06.2010
IPC:
C07D 403/12 (2006.01), C07D 405/14 (2006.01), C07D 409/14 (2006.01), C07D 413/12 (2006.01), C07D 413/14 (2006.01), C07D 417/12 (2006.01), C07D 417/14 (2006.01), A61K 31/4045 (2006.01), A61P 25/28 (2006.01)
Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D [BE/BE]; Minderbroedersstraat 8a - box 5105 B-3000 Leuven (BE) (For All Designated States Except US).
reMYND [BE/BE]; Gaston Geenslaan 1 B-3001 Heverlee (BE) (For All Designated States Except US).
GRIFFIOEN, Gerard [NL/BE]; (BE) (For US Only).
VAN DOOREN, Tom [BE/BE]; (BE) (For US Only).
ROJAS DE LA PARRA, Veronica [MX/BE]; (BE) (For US Only).
MARCHAND, Arnaud [FR/BE]; (BE) (For US Only).
ALLASIA, Sara [IT/BE]; (BE) (For US Only).
KILONDA, Amuri [BE/BE]; (BE) (For US Only).
CHALTIN, Patrick [BE/BE]; (BE) (For US Only)
Inventors: GRIFFIOEN, Gerard; (BE).
VAN DOOREN, Tom; (BE).
ROJAS DE LA PARRA, Veronica; (BE).
MARCHAND, Arnaud; (BE).
ALLASIA, Sara; (BE).
KILONDA, Amuri; (BE).
CHALTIN, Patrick; (BE)
Agent: BOUNAGA, Sakina; De Clercq & Partners E. Gevaertdreef 10a B-9830 Sint-Martens-Latem (BE)
Priority Data:
0910003.3 11.06.2009 GB
Title (EN) INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
(FR) DÉRIVÉS D'INDOLAMIDE ET COMPOSÉS ASSOCIÉS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DES MALADIES NEURODÉGÉNÉRATIVES
Abstract: front page image
(EN)This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.
(FR)La présente invention a pour objet de nouveaux composés et les nouveaux composés destinés à être utilisés en tant que médicaments, plus particulièrement pour la prévention ou le traitement des troubles neurodégénératifs, plus spécifiquement certains troubles neurologiques, tels que les troubles connus collectivement sous le nom de tauopathies, et les troubles caractérisés par une amyloïdogenèse cytotoxique par l'α–synucléine. La présente invention concerne également l'utilisation desdits nouveaux composés pour la fabrication de médicaments utiles pour le traitement de tels troubles neurodégénératifs. La présente invention concerne en outre des compositions pharmaceutiques comprenant lesdits nouveaux composés et des procédés pour la préparation desdits nouveaux composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)