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1. WO2010142628 - PYRAZOLE OXADIAZOLE DERIVATIVES AS S1P1 AGONISTS

Publication Number WO/2010/142628
Publication Date 16.12.2010
International Application No. PCT/EP2010/057893
International Filing Date 07.06.2010
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245
Oxadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
C07D 413/04 (2006.01)
C07D 413/14 (2006.01)
C07D 471/04 (2006.01)
A61K 31/4245 (2006.01)
A61P 37/06 (2006.01)
CPC
C07D 231/10
C07D 271/06
C07D 413/04
C07D 413/14
C07D 471/04
Applicants
  • MERCK SERONO S.A. [CH/CH]; Centre industriel CH-1267 Coinsins, CH (AllExceptUS)
  • QUATTROPANI, Anna [CH/CH]; CH (UsOnly)
  • BAKER-GLENN, Charles [GB/GB]; GB (UsOnly)
  • BLACKABY, Wesley [GB/GB]; GB (UsOnly)
  • KNIGHT, Chris [GB/GB]; GB (UsOnly)
Inventors
  • QUATTROPANI, Anna; CH
  • BAKER-GLENN, Charles; GB
  • BLACKABY, Wesley; GB
  • KNIGHT, Chris; GB
Agents
  • MERCK SERONO INTERNATIONAL S.A. INTELLECTUAL PROPERTY; 9 chemin des Mines CH-1202 Geneva, CH
Priority Data
09162206.808.06.2009EP
61/218,47719.06.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRAZOLE OXADIAZOLE DERIVATIVES AS S1P1 AGONISTS
(FR) DÉRIVÉS PYRAZOLES OXADIAZOLES EN TANT QU'AGONISTES DE S1P1
Abstract
(EN)
The present invention relates to pyrazole oxadiazoles derivatives of Formula (I), and their use for treating multiple sclerosis and other diseases. Wherein R1, R2 and R3 are as defined in the description.
(FR)
La présente invention porte sur des dérivés pyrazoles oxadiazoles de Formule (I) et sur leur utilisation pour traiter une sclérose en plaque et autres maladies, formule dans laquelle R1, R2 et R3 sont tels que définis dans la description.
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