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1. (WO2010142124) NEW USES OF MEDICINES WITH ADAMANTANE STRUCTURE AND THEIR DERIVATIVES AND ANALOGUES IN TREATING TUMOR-RELATED DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/142124 International Application No.: PCT/CN2009/076061
Publication Date: 16.12.2010 International Filing Date: 25.12.2009
IPC:
C07C 211/38 (2006.01) ,C07C 211/19 (2006.01) ,C07C 237/14 (2006.01) ,C07C 65/26 (2006.01) ,C07C 49/513 (2006.01) ,A61K 31/13 (2006.01) ,A61K 31/16 (2006.01) ,A61K 31/192 (2006.01) ,A61K 31/122 (2006.01) ,A61P 35/00 (2006.01) ,A61P 31/00 (2006.01) ,A61P 31/04 (2006.01) ,A61P 31/10 (2006.01) ,A61P 31/12 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
33
having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
34
of a saturated carbon skeleton
38
containing condensed ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
16
of a saturated carbon skeleton containing rings other than six-membered aromatic rings
19
containing condensed ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02
having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
14
the carbon skeleton being saturated and containing rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
65
Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
21
containing ether groups, groups, groups, or groups
24
polycyclic
26
containing rings other than six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
49
Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
385
Saturated compounds containing a keto group being part of a ring
487
containing hydroxy groups
507
polycyclic
513
a keto group being part of a condensed ring system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
122
having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10
Antimycotics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants: XU, Lifeng[CN/CN]; CN (UsOnly)
LIAONING LIFENG SCIENTIFIC & TECHNOLOGY DEVELOPMENT COMPANY LTD.[CN/CN]; 90 Bawang Si Street, Dadong Shenyang, Liaoning 110044, CN (AllExceptUS)
Inventors: XU, Lifeng; CN
Priority Data:
200910146141.311.06.2009CN
Title (EN) NEW USES OF MEDICINES WITH ADAMANTANE STRUCTURE AND THEIR DERIVATIVES AND ANALOGUES IN TREATING TUMOR-RELATED DISEASES
(FR) NOUVELLES UTILISATIONS DE MÉDICAMENTS AYANT UNE STRUCTURE D'ADAMANTANE ET LEURS DÉRIVÉS ET ANALOGUES DANS LE TRAITEMENT DE MALADIES ASSOCIÉES À DES TUMEURS
(ZH) 具有金刚烷结构药物及其衍生物和类似物抗肿瘤新适应症的应用
Abstract:
(EN) Medicines with adamantane structure and their derivatives and analogues having new activity and indications such as antitumor, and their uses as medicine for treating some diseases such as tumor. The medicines are the compounds having the following structures, the derivatives and analogues deriving from the structures, the new structural compounds deriving from the parent or fragment structures, the compounds having the same or different structures and the similar or relative bioactivities by predigesting, expanding the said structure or/and by replacing the said structure on the basis of isosterism, their salts, double salts and the prodrugs thereof. These compounds can be in combination with other therapeutic agents to use as antitumor medicine for treating tumor-related or tumor-accompanying diseases, including viral diseases, bacterial diseases, fungal diseases, nervous system diseases, endocrine system diseases, immune system diseases and so on.
(FR) La présente invention concerne des médicaments ayant une structure d'adamantane et leurs dérivés et analogues ayant de nouvelles activité et indications telles qu'une indication anticancéreuse, et leurs utilisations en tant que médicament pour traiter certaines maladies telles que des tumeurs. Les médicaments sont les composés ayant les structures suivantes, les dérivés et analogues dérivés des structures, les nouveaux composés structuraux dérivés des structures parentes ou fragmentaires, les composés ayant des structures identiques ou différentes et des bioactivités similaires ou relatives par prédigestion, expansion de ladite structure et/ou par remplacement de ladite structure sur la base de l'isostérie, leurs sels, doubles sels et les promédicaments de ceux-ci. Ces composés peuvent être en association avec d'autres agents thérapeutiques pour utilisation en tant que médicament anticancéreux pour traiter des maladies associées à des tumeurs ou accompagnant des tumeurs, comprenant des maladies virales, des maladies bactériennes, des maladies fongiques, des maladies du système nerveux, des maladies du système endocrine, des maladies du système immunitaire, etc.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)