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1. (WO2010141738) COMPOSITIONS AND METHOD FOR INHIBITING TUMOR GROWTH
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/141738    International Application No.:    PCT/US2010/037280
Publication Date: 09.12.2010 International Filing Date: 03.06.2010
IPC:
A61K 31/438 (2006.01), A61K 31/44 (2006.01), A61K 31/4412 (2006.01), A61K 31/443 (2006.01), A61P 35/00 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138 (US) (For All Designated States Except US).
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street Boston, MA 02115 (US) (For All Designated States Except US).
BALDWIN, Amy [US/US]; (US) (For US Only).
GRUENEBERG, Dorre [US/US]; (US) (For US Only).
HARLOW, Ed [US/US]; (US) (For US Only).
XIAN, Jun [US/US]; (US) (For US Only).
MUNGER, Karl [CH/US]; (US) (For US Only).
HELLNER, Karin [DE/US]; (US) (For US Only).
GLICKSMAN, Marcie [US/US]; (US) (For US Only).
STEIN, Ross [US/US]; (US) (For US Only).
CUNY, Gregory [US/US]; (US) (For US Only)
Inventors: BALDWIN, Amy; (US).
GRUENEBERG, Dorre; (US).
HARLOW, Ed; (US).
XIAN, Jun; (US).
MUNGER, Karl; (US).
HELLNER, Karin; (US).
GLICKSMAN, Marcie; (US).
STEIN, Ross; (US).
CUNY, Gregory; (US)
Agent: BEATTIE, Ingrid, A.; Mintz Levin Cohn Ferris Glovsky And Popeo, P.C. One Financial Center Boston, MA 02111 (US)
Priority Data:
61/183,851 03.06.2009 US
Title (EN) COMPOSITIONS AND METHOD FOR INHIBITING TUMOR GROWTH
(FR) COMPOSITIONS ET PROCÉDÉ POUR INHIBER LA CROISSANCE D'UNE TUMEUR
Abstract: front page image
(EN)The invention provides methods and compositions for inhibiting p53 -inactivated cancers. Cancer cells are preferentially inhibited compared to normal cells by inhibiting tumor survival kinases that are required for growth of tumor cells but not normal cells.
(FR)L'invention concerne des procédés et des compositions pour inhiber des cancers à p53 inactivé. Les cellules cancéreuses sont inhibées préférentiellement en comparaison des cellules normales par inhibition des kinases de la survie tumorale qui sont nécessaires pour la croissance des cellules tumorales mais pas des cellules normales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)