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Pub. No.:    WO/2010/141391    International Application No.:    PCT/US2010/036760
Publication Date: 09.12.2010 International Filing Date: 28.05.2010
C12N 9/10 (2006.01), C12N 15/54 (2006.01), C12N 15/63 (2006.01)
Applicants: LIFE TECHNOLOGIES CORPORATION [US/US]; 5791 Van Allen Way Carlsbad, California 92008 (US) (For All Designated States Except US).
PERIS, Marian [US/US]; (US) (For US Only).
PHELAN, Michael [US/US]; (US) (For US Only).
ROSENBLUM, Barnett B. [US/US]; (US) (For US Only).
HENDRICKS, Stephen P. [US/US]; (US) (For US Only)
Inventors: PERIS, Marian; (US).
PHELAN, Michael; (US).
ROSENBLUM, Barnett B.; (US).
HENDRICKS, Stephen P.; (US)
Agent: GERMAN, Roberta; Life Technologies Corporation Attention: IP Department 5791 Van Allen Way Carlsbad, CA 92008 (US)
Priority Data:
61/184,774 05.06.2009 US
61/242,762 15.09.2009 US
61/263,320 20.11.2009 US
61/295,533 15.01.2010 US
Abstract: front page image
(EN)Provided herein are mutant DNA-dependent polymerases which are derived from, or otherwise related to, wild type RB69 DNA polymerase. These mutant polymerases are capable of selectively binding labeled nucleotides. These mutant polymerases are also capable of incorporating a variety of naturally occurring and modified nucleotides, including, for example, terminator nucleotides.
(FR)Les polymérases ADN-dépendantes mutantes ci-décrites sont dérivées de, ou à part cela, apparentées à, l'ADN polymérase de type sauvage du RB69. Ces polymérases mutantes sont capables de se lier sélectivement à des nucléotides marqués. Ces polymérases mutantes sont également capables d'incorporer toute une variété de nucléotides naturels et modifiés, comprenant, par exemple, des nucléotides de terminaison.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)