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1. (WO2010141312) FLAGELLIN FUSION PROTEINS AND CONJUGATES COMPRISING PNEUMOCOCCUS ANTIGENS AND METHODS OF USING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/141312 International Application No.: PCT/US2010/036369
Publication Date: 09.12.2010 International Filing Date: 27.05.2010
IPC:
A61K 38/16 (2006.01) ,A61K 39/09 (2006.01) ,A61K 39/116 (2006.01) ,C07K 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
09
Streptococcus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
116
Polyvalent bacterial antigens
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
Applicants:
WAKE FOREST UNIVERSITY HEALTH SCIENCES [US/US]; 391 Technology Way, Suite 199 Winston-Salem, North Carolina 27101, US (AllExceptUS)
MIZEL, Steven B. [US/US]; US (UsOnly)
REID, Sean [US/US]; US (UsOnly)
Inventors:
MIZEL, Steven B.; US
REID, Sean; US
Agent:
MYERS BIGEL SIBLEY & SAJOVEC, P.A.; P.O. Box 37428 Raleigh, North Carolina 27627, US
Priority Data:
61/182,97801.06.2009US
Title (EN) FLAGELLIN FUSION PROTEINS AND CONJUGATES COMPRISING PNEUMOCOCCUS ANTIGENS AND METHODS OF USING THE SAME
(FR) PROTÉINES DE FUSION FLAGELLINE ET CONJUGUÉS COMPRENANT DES ANTIGÈNES PNEUMOCOQUES ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The present invention is based, in part, on flagellin adjuvant used to enhance immune responses directed against Streptococcus pneumoniae, in particular, to enhance immune responses to polypeptide antigens (e.g., PspA) and capsular polysaccharide from S. pneumoniae. In representative embodiments, the invention provides a fusion protein comprising a flagellin adjuvant and one more polypeptide antigens from S. pneumoniae. In other embodiments, the invention provides a conjugate comprising a flagellin adjuvant covalently linked to a capsular polysaccharide from one or more serotypes of S. pneumoniae. Also provided are compositions comprising the fusion proteins and/or conjugates of the invention as well as immunogenic formulations comprising the inventive fusion proteins, conjugates and/or compositions. The invention also provides methods of producing an immune response against S. pneumoniae and methods of protecting a subject from S. pneumoniae infection by administering the fusion proteins, conjugates, compositions and/or immunogenic formulations of the invention to the subject.
(FR) La présente invention concerne, en partie, un adjuvant flagelline utilisé pour améliorer les réponses immunitaires dirigées contre Streptococcus pneumoniae, notamment pour améliorer les réponses immunitaires à des antigènes polypeptidiques (p. ex. PspA) et un polysaccharide capsulaire de S. pneumoniae. Selon des modes de réalisation illustratifs, l'invention concerne une protéine de fusion comprenant un adjuvant flagelline et un ou plusieurs antigènes polypeptidiques de S. pneumoniae. Selon d'autres modes de réalisation, l'invention concerne un conjugué comprenant un adjuvant flagelline relié de manière covalente à un polysaccharide capsulaire d'un ou de plusieurs sérotypes de S. pneumoniae. L'invention concerne également des compositions comprenant les protéines de fusion et/ou les conjugués de l'invention, ainsi que des formulations immunogènes comprenant les protéines de fusion, conjugués et/ou compositions de l'invention. L'invention concerne également des procédés de production d'une réponse immunitaire contre S. pneumoniae et des procédés de protection d'un sujet d'une infection par S. pneumoniae par administration des protéines de fusion, conjugués, compositions et/ou formulations immunogènes de l'invention au sujet.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20120135037