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Machine translation
1. (WO2010141093) CO-SIGNALING METHODS FOR TREATING CANCERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/141093    International Application No.:    PCT/US2010/001625
Publication Date: 09.12.2010 International Filing Date: 04.06.2010
IPC:
A61K 38/16 (2006.01), A61K 38/20 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01)
Applicants: THE UNIVERSITY OF MARYLAND, BALTIMORE [US/US]; 520 West Lombard Street Baltimore, MD 21201-1627 (US) (For All Designated States Except US).
STROME, Scott, E. [US/US]; (US) (For US Only).
SCHULZE, Dan, H. [US/US]; (US) (For US Only).
CHAPOVAL, Andrei [US/US]; (US) (For US Only)
Inventors: STROME, Scott, E.; (US).
SCHULZE, Dan, H.; (US).
CHAPOVAL, Andrei; (US)
Agent: ADLER, Benjamin, Aaron; Adler & Associates 8011 Candle Lane Houston, TX 77071 (US)
Priority Data:
61/184,000 04.06.2009 US
Title (EN) CO-SIGNALING METHODS FOR TREATING CANCERS
(FR) MÉTHODES DE CO-SIGNALEMENT PERMETTANT DE TRAITER LES CANCERS
Abstract: front page image
(EN)Provided herein is a method of treating a neoplastic disease in an individual in need of such treatment, comprising the steps of: expanding γδ T lymphocytes in vitro; priming Natural Kill cells in vitro; and administering said expanded γδ T lymphocytes and said primed Natural Kill cells to said individual, thereby resulting in a cytotoxic or cytolytic effect. Further provided is a method of treating a neoplastic disease in an individual in need of such treatment, comprising the steps of: administering a compound to said individual that activates yδ T lymphocytes; and administering an antibody directed against a tumor antigen associated with said neoplastic disease.
(FR)La présente invention concerne une méthode de traitement d'une maladie néoplasique chez un individu ayant besoin d'un tel traitement, ladite méthode comprenant les étapes consistant à multiplier des lymphocytes T γδ in vitro ; à sensibiliser des cellules NK in vitro ; et à administrer lesdits lymphocytes T γδ multipliés et lesdites cellules NK sensibilisées audit individu, avec pour résultat un effet cytotoxique ou cytolytique. L'invention concerne, en outre, une méthode de traitement d'une maladie néoplasique chez un individu ayant besoin d'un tel traitement, ladite méthode comprenant les étapes consistant à administrer audit individu un composé capable d'activer les lymphocytes T yδ, puis un anticorps dirigé contre un antigène tumoral associé à ladite maladie néoplasique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)