WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2010141039) ISOLATION AND PURIFICATION OF ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/141039    International Application No.:    PCT/US2009/061329
Publication Date: 09.12.2010 International Filing Date: 20.10.2009
Chapter 2 Demand Filed:    20.05.2010    
IPC:
C07K 16/00 (2006.01), C07K 16/24 (2006.01)
Applicants: ABBOTT LABORATORIES [US/US]; 100 Abott Park Road Abbott Park, IL 60064-6008 (US) (For All Designated States Except US).
HICKMAN, Robert, K. [US/US]; (US) (For US Only).
HUANG, Qing [US/US]; (US) (For US Only).
WEED, Cheryl, L. [US/US]; (US) (For US Only).
ENNIS, Scott, T. [US/US]; (US) (For US Only).
PERILLI-PALMER, Barbara [US/US]; (US) (For US Only).
WAN, Min [US/US]; (US) (For US Only)
Inventors: HICKMAN, Robert, K.; (US).
HUANG, Qing; (US).
WEED, Cheryl, L.; (US).
ENNIS, Scott, T.; (US).
PERILLI-PALMER, Barbara; (US).
WAN, Min; (US)
Agent: KOLE, Lisa, B.; Baker Botts LLP 30 Rockefeller Plaza New York, NY 10112-4498 (US).
GAUDET, Stephen, J.; 100 Research Drive Worcester, MA 01605 (US)
Priority Data:
61/196,753 20.10.2008 US
Title (EN) ISOLATION AND PURIFICATION OF ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY
(FR) ISOLEMENT ET PURIFICATION D'ANTICORPS PAR CHROMATOGRAPHIE D'AFFINITÉ DE LA PROTÉINE A
Abstract: front page image
(EN)Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
(FR)L'invention concerne des procédés d'isolement et de purification d'anticorps selon lesquels l'utilisation d'une étape de chromatographie d'affinité permet d'obtenir une composition d'anticorps suffisamment pure pour être utilisée à des fins pharmaceutiques. Lesdits procédés comprennent les opérations suivantes: réduction/inactivation par pH, ultrafiltration/diafiltration, chromatographie d'affinité, de préférence d'affinité de la protéine A, chromatographie à échange d'ions et chromatographie hydrophobe. L'invention s'applique à des compositions pharmaceutiques contenant un anticorps de la présente invention ou davantage.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)