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1. (WO2010140734) COMPOSITION FOR PREVENTING OR TREATING OBESITY-RELATED DISEASES MEDIATED BY THE ACTIVATION OF AMPK AND INCLUDING 2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS AS ACTIVE INGREDIENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/140734    International Application No.:    PCT/KR2009/003471
Publication Date: 09.12.2010 International Filing Date: 26.06.2009
IPC:
A61K 36/185 (2006.01)
Applicants: INDUSTRY ACADEMY COOPERATION FOUNDATION CHOSUN UNIVERSITY [KR/KR]; 375, Seoseok-dong, Dong-gu GwangJoo 501-759 (KR) (For All Designated States Except US).
AMOREPACIFIC CORPORATION [KR/KR]; 181, Hangangro 2-ga, Yongsan-gu Seoul 140-777 (KR) (For All Designated States Except US).
OH, Won Keun [KR/KR]; (KR) (For US Only).
NGUYEN, Phi Hung [VN/VN]; (VN) (For US Only).
LE, Thi Van Thu [VN/VN]; (VN) (For US Only).
KANG, Hu Won [KR/KR]; (KR) (For US Only).
SHIN, Eui Seok [KR/KR]; (KR) (For US Only).
CHIO, Jin Kyu [KR/KR]; (KR) (For US Only).
SEO, Dae Bang [KR/KR]; (KR) (For US Only).
LEE, Sang Jun [KR/KR]; (KR) (For US Only)
Inventors: OH, Won Keun; (KR).
NGUYEN, Phi Hung; (VN).
LE, Thi Van Thu; (VN).
KANG, Hu Won; (KR).
SHIN, Eui Seok; (KR).
CHIO, Jin Kyu; (KR).
SEO, Dae Bang; (KR).
LEE, Sang Jun; (KR)
Agent: BAIK, Kyong Up; 5th F1, Korea Development Bank Bldg. 946, Doonsan2-dong, Seo-gu Daejeon 302-828 (KR)
Priority Data:
10-2009-0048065 01.06.2009 KR
Title (EN) COMPOSITION FOR PREVENTING OR TREATING OBESITY-RELATED DISEASES MEDIATED BY THE ACTIVATION OF AMPK AND INCLUDING 2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS AS ACTIVE INGREDIENTS
(FR) COMPOSITION, POUR LA PRÉVENTION OU LE TRAITEMENT D'AFFECTIONS LIÉES À L'OBÉSITÉ ET MÉDIÉES PAR L'ACTIVATION D'AMPK, ET DONT LES PRINCIPES ACTIFS DONT DES LIGNANES DE 2,5-BIS-ARYL-3,4-DIMÉTHYLTÉTRAHYDROFURANE
(KO) 2,5-비스-아릴-3,4-디메틸테트라하이드로퓨란 리그난을 유효성분으로 포함하는 에이엠피케이의 활성화에 의해 매개되는 비만 관련 질환의 예방 또는 치료용 조성물
Abstract: front page image
(EN)The present invention relates to a 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan compound which activates nutmeg-derived AMP-activated protein kinase (AMPK), and to a composition including same as active ingredients for preventing and treating metabolic syndromes such as obesity. More particularly, the present invention relates to an AMPK-activating compound comprising one of the 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan-based compounds produced by extracting Myristica fragrans with a solution of 30% or less of ethanol and separating and purifying the extracts using chromatography, as expressed in chemical formula 1 below, and to a composition comprising same as an active ingredient for preventing and treating metabolic syndrome-related diseases caused by AMPK enzyme activation, such as obesity, diabetes, high cholesterol and cardiopulmonary diseases.
(FR)La présente invention concerne, d'une part un composé à base de lignane de 2,5-bis-aryl-3,4-diméthyltétrahydrofurane qui active la protéine kinase AMPK activée par une adénosine monophosphate tirée de la muscade, et d'autre part une composition dont ce composé est un principe actif, et qui est destinée à la prévention et au traitement de syndromes métaboliques tels que l'obésité. L'invention concerne plus particulièrement, d'une part un composé activant l'AMPK et comprenant l'un des produits à base de lignane de 2,5-bis-aryl-3,4-diméthyltétrahydrofurane obtenus par extraction de Myristica fragrans au moyen d'une solution à 30% au maximum d'éthanol, puis par séparation et purification des extraits par chromatographie, selon la formule chimique 1, et d'autre part une composition dont ce composé est un principe actif, et qui est destinée à la prévention et au traitement d'affections liées au syndrome métabolique découlant de l'activation de l'enzyme AMPK, telles que l'obésité, le diabète, l'hypercholestérolémie, et les maladies cardio-pulmonaires.
(KO)본 발명은 육두구 유래의 AMP-활성 단백질키나제 효소(AMP-activated protein kinase; AMPK)를 활성화시키는 2,5-비스-아릴-3,4-디메틸테트라하이드로퓨란 리그난계 화합물 및 이를 유효성분으로 포함하는 비만과 같은 대사증후군(metabolic syndrome)의 예방과 치료용 조성물에 관한 것으로, 더욱 상세하게는 육두구를 30%이하 에탄올 수용액으로 추출한 후 크로마토그래피를 이용하여 순수 분리 정제하여 얻은 하기 화학식 1로 표시되는 2,5-비스-아릴-3,4-디메틸테트라하이드로퓨란 리그난계 화합물 중 어느 하나를 포함하는 AMPK 활성화 화합물과 이를 유효성분으로 함유하는 비만, 당뇨, 고지혈증, 심혈관계 질환 등과 같은 AMPK 효소의 활성화에 따른 대사증후군 관련 질환의 예방 및 치료용 조성물에 관한 것이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)