WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2010140694) METHOD FOR SCREENING OF INHIBITOR USING FACTOR CAPABLE OF ENHANCING PRODUCTION OF AMYLOID-BETA PEPTIDE, AND INHIBITOR OBTAINED BY SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/140694    International Application No.:    PCT/JP2010/059568
Publication Date: 09.12.2010 International Filing Date: 04.06.2010
IPC:
A61K 45/00 (2006.01), A61K 31/7088 (2006.01), A61K 31/7105 (2006.01), A61K 39/395 (2006.01), A61K 48/00 (2006.01), A61P 25/28 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01)
Applicants: Dainippon Sumitomo Pharma Co., Ltd. [JP/JP]; 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418524 (JP) (For All Designated States Except US).
TJERNBERG, O. Lars [SE/SE]; (SE) (For US Only).
FRYKMAN, Susanne [SE/SE]; (SE) (For US Only).
HUR, JI-Yeun [KR/SE]; (SE) (For US Only).
TERANISHI, Yasuhiro [JP/JP]; (JP) (For US Only).
NAKAGAWA, Hiroyuki [JP/JP]; (JP) (For US Only).
SAKAI, Jun [JP/JP]; (JP) (For US Only).
KIHARA, Takahiro [JP/SE]; (SE) (For US Only).
ISHIKAWA, Taizo [JP/JP]; (JP) (For US Only)
Inventors: TJERNBERG, O. Lars; (SE).
FRYKMAN, Susanne; (SE).
HUR, JI-Yeun; (SE).
TERANISHI, Yasuhiro; (JP).
NAKAGAWA, Hiroyuki; (JP).
SAKAI, Jun; (JP).
KIHARA, Takahiro; (SE).
ISHIKAWA, Taizo; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044 (JP)
Priority Data:
2009-135589 04.06.2009 JP
Title (EN) METHOD FOR SCREENING OF INHIBITOR USING FACTOR CAPABLE OF ENHANCING PRODUCTION OF AMYLOID-BETA PEPTIDE, AND INHIBITOR OBTAINED BY SAME
(FR) PROCÉDÉ POUR LE CRIBLAGE D'INHIBITEUR UTILISANT UN FACTEUR CAPABLE DE STIMULER LA PRODUCTION DE PEPTIDE AMYLOÏDE BÊTA, ET INHIBITEUR OBTENU PAR CELUI-CI
(JA) アミロイドベータペプチドの産生を促進する因子を用いた阻害剤のスクリーニング方法及びそれによって得られる阻害剤
Abstract: front page image
(EN)Disclosed is a novel and effective therapeutic agent for Alzheimer's disease. Specifically disclosed are: a β-amyloid (Aβ) production inhibitor, which comprises a substance capable of inhibiting the expression or function of a protein selected from probable phospholipid-transporting ATPase IIA; a BDNF/NT-3 growth factors receptor precursor; ELAV-like protein 4; coiled-coil domain-containing protein 136; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; DnaJ homolog subfamily A member 2; vesicle-associated membrane protein-associated protein A; a proton myo-inositol cotransporter; leukocyte surface antigen CD47; flotillin-1; band 4.1 like 1; a regulator of G-protein signaling 7; phospholipase D3; ectoderm-neural cortex protein 1; synaptophysin; solute carrier family 2 (a facilitated glucose transporter), member 3; syntaxin binding protein 1; growth associated protein 43; ATPase, Na+/K+ transporting, beta 1 polypeptide; amine oxidase [flavin-containing] B; muscarinic acetylcholine receptor M1; a probable cationic amino acid transporter; NADH dehydrogenase iron-sulfur protein 7; a G-protein-regulated inducer of neurite outgrowth; and probable phospholipid-transporting ATPase 1A; and a method for screening an Aβ production-inhibiting substance or a prophylactic/therapeutic agent for Alzheimer's disease, which uses the protein.
(FR)La présente invention concerne un agent thérapeutique nouveau et efficace pour la maladie d'Alzheimer. La présente invention concerne spécifiquement : un inhibiteur de production de β-amyloïde (Aβ), qui comprend une substance capable d'inhiber l'expression ou la fonction d'une protéine choisie parmi l'ATPase IIA transporteur de phospholipide probable ; un précurseur de récepteur de facteurs de croissance BDNF/NT-3 ; la protéine 4 de type ELAV ; la protéine 136 contenant un domaine hélicoïdal ; le canal 2 déclenché par nucléotide cyclique activé par hyperpolarisation potassium/sodium ; le membre 2 de la sous-famille A d'homologues de DnaJ ; la protéine A associée à la protéine membranaire associée aux vésicules ; un cotransporteur de myo-inositol protonique ; l'antigène de surface de leucocytes CD47 ; la flotilline-1 ; band-4.1-like 1; un régulateur de la signalisation de protéine G 7 ; la phospholipase D3 ; la protéine 1 d'ectoderme-cortex neural ; la synaptophysine ; la famille de véhicule de soluté 2 (un transporteur de glucose facilité), membre 3 ; la protéine de liaison de syntaxine 1 ; la protéine associée à la croissance 43 ; le polypeptide bêta 1, ATPase, transporteur de Na+/K+ ; l'amine oxydase [contenant de la flavine] B ; le récepteur M1 d'acétylcholine muscarinique ; un transporteur d'acide aminé cationique probable ; la protéine 7 NADH déshydrogénase à fer-soufre ; un inducteur régulé par la protéine G de croissance de neurite ; et l'ATPase transporteur de phospholipide probable 1A ; et un procédé pour cribler une substance inhibitrice de production de Aβ ou un agent prophylactique/thérapeutique pour la maladie d'Alzheimer, qui utilise la protéine.
(JA) 本発明は、新規かつ有効なアルツハイマー病治療薬を提供する。具体的には、Probable phospholipid-transporting ATPase IIA;BDNF/NT-3 growth factors receptor precursor;ELAV-like protein 4;Coiled-coil domain-containing protein 136;Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2;DnaJ homolog subfamily A member 2;Vesicle-associated membrane protein-associated protein A;Proton myo-inositol cotransporter;Leukocyte surface antigen CD47;Flotillin-1;Band 4.1 like 1;Regulator of G-protein signaling 7;Phospholipase D3;Ectoderm-neural cortex protein 1;synaptophysin;solute carrier family 2 (facilitated glucose transporter), member 3;syntaxin binding protein 1;growth associated protein 43;ATPase, Na+/K+ transporting, beta 1 polypeptide;Amine oxidase [flavin-containing] B;Muscarinic acetylcholine receptor M1;Probable cationic amino acid transporter;NADH dehydrogenase iron-sulfur protein 7;G-protein-regulated inducer of neurite outgrowth;およびProbable phospholipid-transporting ATPase 1Aから選ばれるタンパク質の発現もしくは機能を抑制する物質を含有してなる、βアミロイド(Aβ)産生抑制剤、前記タンパク質を用いたAβ産生抑制物質、アルツハイマー病の予防・治療薬のスクリーニング方法が提供される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)