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1. (WO2010139827) INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/139827    International Application No.:    PCT/ES2010/000258
Publication Date: 09.12.2010 International Filing Date: 04.06.2010
IPC:
C07D 295/104 (2006.01), A61K 31/4709 (2006.01), A61K 31/472 (2006.01)
Applicants: LABORATORIOS SALVAT, S.A. [ES/ES]; C/ Gall, 30-36 E-08950 Esplugues de Llobregat (Barcelona) (ES) (For All Designated States Except US).
CATENA RUIZ, Juan Lorenzo [ES/ES]; (ES) (For US Only).
SERRA COMAS, Carme [ES/ES]; (ES) (For US Only).
REY PUIGGROS, Oscar [ES/ES]; (ES) (For US Only).
ANTOLIN HERNANDEZ, Albert [ES/ES]; (ES) (For US Only).
MONLLEO MAS, Ester [ES/ES]; (ES) (For US Only)
Inventors: CATENA RUIZ, Juan Lorenzo; (ES).
SERRA COMAS, Carme; (ES).
REY PUIGGROS, Oscar; (ES).
ANTOLIN HERNANDEZ, Albert; (ES).
MONLLEO MAS, Ester; (ES)
Priority Data:
P200901402 04.06.2009 ES
Title (EN) INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
(ES) COMPUESTOS INHIBIDORES DE 11 BETA-HIDROXIESTEROIDE DESHIDROGENASE DE TIPO 1
(FR) COMPOSÉS INHIBITEURS DE 11-BÊTA-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1
Abstract: front page image
(EN)The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and can be used as pharmaceutical active principles for the prophylaxis or treatment of diseases caused by disorders associated with the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme (11-beta-HSD1), such as glaucoma, elevated ocular pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, cognitive changes, Alzheimer's disease, or neurodegeneration.
(ES)Los compuestos de fórmula (I) son derivados de perhidroquinolina y perhidroisoquinolina y son útiles como principios activos farmacéuticos para Ia profilaxis o tratamiento de enfermedades causadas por trastornos asociados con Ia enzima 11 beta-hidroxiesteroide deshidrogenasa de tipo 1 (11 beta- HSD1), tales como glaucoma, presión ocular elevada, trastornos metabólicos, obesidad, síndrome metabólico, dislipidemia, hipertensión, diabetes, aterosclerosis, síndrome de Cushing, psoriasis, artritis reumatoide, alteraciones de Ia cognición, enfermedad de Alzheimer o neurodegeneración.
(FR)L'invention concerne des composés de formule (I) dérivés de perhydroquinoline et de perhydroisoquinoline et utiles comme principes actifs pharmaceutiques pour la prévention ou le traitement de maladies causées par des troubles associés à l'enzyme 11-bêta-hydroxystéroïde déshydrogénase de type 1 (11-bêta-HSD1), telles que le glaucome, l'hypertension oculaire, les troubles métaboliques, l'obésité, le syndrome métabolique, la dyslipidémie, l'hypertension, le diabète, l'athérosclérose, le syndrome de Cushing, le psoriasis, l'arthrite rhumatoïde, les altérations cognitives, la maladie d'Alzheimer ou la neurodégénérescence.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)