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1. (WO2010139678) TREATMENT OF MAMMALIAN DISORDERS MEDIATED BY ALPHA-CARBONIC ANHYDRASE ISOFORMS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/139678    International Application No.:    PCT/EP2010/057598
Publication Date: 09.12.2010 International Filing Date: 01.06.2010
IPC:
A61K 31/506 (2006.01), A61K 45/06 (2006.01), A61P 35/00 (2006.01), A61P 27/06 (2006.01), A61P 25/06 (2006.01), A61P 3/04 (2006.01), A61P 3/14 (2006.01)
Applicants: UNIVERSITY OF TAMPERE [FI/FI]; Kalevantie 2 FIN-33014 Tampere (FI) (For All Designated States Except US).
SUPURAN, Claudiu [IT/IT]; (IT).
PARKKILA, Seppo [FI/FI]; (FI) (For US Only)
Inventors: SUPURAN, Claudiu; (IT).
PARKKILA, Seppo; (FI)
Agent: BOEHMERT & BOEHMERT; Att. Jan B. Krauss Pettenkoferstrasse 20-22 80336 Munich (DE)
Priority Data:
09161720.9 02.06.2009 EP
Title (EN) TREATMENT OF MAMMALIAN DISORDERS MEDIATED BY ALPHA-CARBONIC ANHYDRASE ISOFORMS
(FR) TRAITEMENT DE TROUBLES CHEZ DES MAMMIFÈRES AU MOYEN D'ISOFORMES DE L'ALPHA-CARBONIQUE ANHYDRASE
Abstract: front page image
(EN)The present invention pertains to 4-(4-methylρiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin- 3-yl)pyrimidin-2-ylamino)phenyl]-benzamide or a pharmaceutically acceptable salt thereof, or 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino}-Λ/-[5-(4--methyl-1H-imidazol-1-yl)-3-(trifluoro- methy!)phenyl] benzamide or a pharmaceutically acceptable salt thereof, for the treatment of disorders mediated by alpha-carbonic anhydrase isoforms selected from intraocular hypertension (glaucoma), epilepsy, Lennox-Gastaut syndrome, altitude sickness, headaches, neurological disorders and obesity.
(FR)La présente invention porte sur le 4-(4-méthylpipérazine-1-ylméthyl)-N-[4-méthyl-3-(4-pyridine-3-yl)pyrimidine-2-ylamino)phényl]-benzamide ou un sel pharmaceutiquement acceptable correspondant, ou sur le 4-méthyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino}-N-[5-(4--méthyl-1H-imidazol-1-yl)-3-(trifluoro-méthyl)phényl]benzamide ou un sel pharmaceutiquement acceptable correspondant, pour le traitement de troubles au moyen d'isoformes de l'alpha-carbonique anhydrase choisis pour une hypertension intraoculaire (glaucome), l'épilepsie, le syndrome de Lennox-Gastaut, le mal de l'altitude, les maux de tête, les troubles neurologiques et l'obésité.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)