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1. (WO2010139673) CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/139673    International Application No.:    PCT/EP2010/057581
Publication Date: 09.12.2010 International Filing Date: 01.06.2010
IPC:
C07D 265/10 (2006.01), C07D 413/06 (2006.01), C07D 413/10 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173 55216 Ingelheim am Rhein (DE) (For All Designated States Except US).
HIMMELSBACH, Frank [DE/DE]; (DE) (For US Only)
Inventors: HIMMELSBACH, Frank; (DE)
Agent: HAMMANN, Heinz; Binger Str. 173 55216 Ingelheim Am Rhein (DE)
Priority Data:
61/217,609 02.06.2009 US
Title (EN) CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
(FR) INHIBITEURS CYCLIQUES DE LA 11 BÉTA-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE 1
Abstract: front page image
(EN)This invention relates to novel compounds of the Formula (I), dependent compounds of Formula (II), (II-A), (II-B), (II-C), (II-D), (II-E), (II-F), (II-G), (II-H), (III), (III-A), (III-B), (III-C), (IV), (IV-A), (IV-B), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
(FR)La présente invention porte sur de nouveaux composés de la Formule (I), des composés dépendants de Formule (II), (II-A), (II-B), (II-C), (II-D), (II-E), (II-F), (II-G), (II-H), (III), (III-A), (III-B), (III-C), (IV), (IV-A), (IV-B), leurs sels pharmaceutiquement acceptables, et sur des compositions pharmaceutiques correspondantes, qui sont utiles pour le traitement thérapeutique de maladies associées à la modulation ou à l'inhibition de 11β-HSD1 chez les mammifères. L'invention porte en outre sur des compositions pharmaceutiques des nouveaux composés et sur des procédés pour leur utilisation dans la réduction ou la régulation de la production de cortisol dans une cellule ou l'inhibition de la conversion de cortisone en cortisol dans une cellule.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)