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1. (WO2010139180) NAPHTHALENE CARBOXAMIDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE AND HISTONE DEACETYLASE, PREPARATION METHODS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/139180    International Application No.:    PCT/CN2010/000272
Publication Date: 09.12.2010 International Filing Date: 05.03.2010
IPC:
C07D 215/22 (2006.01), C07D 215/233 (2006.01), C07D 239/88 (2006.01), C07D 401/12 (2006.01), A61K 31/438 (2006.01), A61K 31/444 (2006.01), A61K 31/517 (2006.01), A61P 3/00 (2006.01), A61P 9/00 (2006.01), A61P 11/00 (2006.01), A61P 25/00 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 37/08 (2006.01)
Applicants: SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. [CN/CN]; 2-601~606, BIO-Incubator, Gaoxin C, 1st Ave. Hi-Tech Industrial Park, Nanshan District Shenzhen, Guangdong 518057 (CN) (For All Designated States Except US).
LU, Xianping [US/CN]; (CN) (For US Only).
LI, Zhibin [CN/CN]; (CN) (For US Only).
SHAN, Song [CN/CN]; (CN) (For US Only).
YU, Jindi [CN/CN]; (CN) (For US Only).
NING, Zhiqiang [CN/CN]; (CN) (For US Only)
Inventors: LU, Xianping; (CN).
LI, Zhibin; (CN).
SHAN, Song; (CN).
YU, Jindi; (CN).
NING, Zhiqiang; (CN)
Agent: AMBOYNA INTELLECTUAL PROPERTY AGENT LTD.; Suite 3-102 Hejingyuan Building A Jimenli, Haidian District Beijing 100088 (CN)
Priority Data:
200910143978.2 04.06.2009 CN
Title (EN) NAPHTHALENE CARBOXAMIDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE AND HISTONE DEACETYLASE, PREPARATION METHODS AND USES THEREOF
(FR) DÉRIVÉS DE NAPHTALÈNE CARBOXAMIDE EN TANT QU'INHIBITEURS DE PROTÉINE KINASE ET D'HISTONE DÉSACÉTYLASE, PROCÉDÉS DE PRÉPARATION ET UTILISATIONS
(ZH) 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
Abstract: front page image
(EN)The naphthalene carboxamide derivatives, the preparation methods and the uses thereof. The structure is shown as the formula (I), wherein the definitions of R1, R2, R3, R4 and Z are the same to those described in the description. The compounds have the protein kinase inhibition activities and the histone deacetylase inhibition activities simultaneously, and can be used for treating diseases related to protein kinase activity abnormity or histone deacetylase activity abnormity, including inflammation, autoimmune diseases, cancer, nervous system diseases and neurodegenerative diseases, metabolic diseases, angiocardiopathy, hypersusceptibility, asthma, and diseases related to hormone.
(FR)Cette invention concerne des dérivés de naphtalène carboxamide, leurs procédés de préparation et leurs utilisations. Leur structure est illustrée dans la formule (I), les définitions de R1, R2, R3, R4 et Z étant identiques à celles indiquées dans la description. Les composés ont simultanément des activités d'inhibition de protéine kinase et des activités d'inhibition d'histone désacétylase, et peuvent être utilisés pour traiter des maladies liées à une anomalie de l'activité protéine kinase ou à une anomalie de l'activité histone désacétylase, comprenant l'inflammation, les maladies auto-immunes, le cancer, les maladies du système nerveux et les maladies neurodégénératives, les maladies métaboliques, l'angiocardiopathie, l'hypersensibilité, l'asthme, et les maladies hormonales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)