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1. (WO2010138769) AMINO ACID SEQUENCES WHICH ENHANCE PEPTIDE CONJUGATE SOLUBILITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/138769    International Application No.:    PCT/US2010/036482
Publication Date: 02.12.2010 International Filing Date: 27.05.2010
IPC:
C07K 16/46 (2006.01), A61K 39/395 (2006.01), C12P 21/08 (2006.01)
Applicants: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS [US/US]; Office of the General Counsel 810 Vermont Avenue NW Washington, DC 20420-0002 (US) (For All Designated States Except US).
WEISBART, Richard, H. [US/US]; (US) (For US Only)
Inventors: WEISBART, Richard, H.; (US)
Agent: HAILE, Lisa, A.; DLA Piper LLP (US) 4365 Executive Drive, Suite 1100 San Diego, CA 92121-2133 (US)
Priority Data:
61/182,030 28.05.2009 US
Title (EN) AMINO ACID SEQUENCES WHICH ENHANCE PEPTIDE CONJUGATE SOLUBILITY
(FR) SÉQUENCES D'ACIDES AMINÉS QUI AMÉLIORENT LA SOLUBILITÉ DE CONJUGUÉS PEPTIDIQUES
Abstract: front page image
(EN)The present invention provides peptide conjugates having improved solubility as well as increased secretion during cell based production, as well as methods of utilizing such peptides. The peptide conjugates include a short peptide domain defined by the amino acid sequence AGIH (SEQ ID NO: 8) and may include a biologically active molecule useful in intracellular and intranuclear transport of the biologically active molecule to treat various disorders and diseases.
(FR)La présente invention porte sur des conjugués peptidiques ayant une solubilité améliorée ainsi qu'une sécrétion améliorée durant une production à base de cellules, ainsi que sur des procédés d'utilisation de tels peptides. Les conjugués peptidiques comprennent un domaine de peptide court défini par la séquence d'acides aminés AGIH (SEQ ID NO: 8) et peuvent comprendre une molécule biologiquement active utile dans le transport intracellulaire et intranucléaire de la molécule biologiquement active pour traiter divers troubles et diverses maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)