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Pub. No.:    WO/2010/138727    International Application No.:    PCT/US2010/036421
Publication Date: 02.12.2010 International Filing Date: 27.05.2010
C12Q 1/68 (2006.01), C07K 14/00 (2006.01)
Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION [US/US]; 614 Walnut Street Madison, WI 53726 (US) (For All Designated States Except US).
ULIJASZ, Andrew, T. [US/US]; (US) (For US Only).
VIERSTRA, Richard, D. [US/US]; (US) (For US Only)
Inventors: ULIJASZ, Andrew, T.; (US).
VIERSTRA, Richard, D.; (US)
Agent: FITZPATRICK, Lynda, M.; Michael Best & Friedrich LLP 100 East Wisconsin Avenue Suite 3300 Milwaukee, WI 53202-4108 (US)
Priority Data:
61/181,578 27.05.2009 US
Abstract: front page image
(EN)Genetically-engineered cyanochrome fluorophore molecules (fluorophores) with increased fluorescence and with absorbing fluorescence in the blue and green (blue/green) portion of the light spectrum are provided. These fluorophores are derived from the domains of phytochromes, and in particular cyanobacterial phytochromes. Methods for generating these fluorophores and various applications of these fluorophores are also provided.
(FR)La présente invention concerne des molécules génétiquement modifiées de fluorophores (fluorophores) à base de cyanochromes présentant une fluorescence accrue dans la partie du spectre optique correspondant au bleu et au vert (bleu/vert). Ces fluorophores relèvent du domaine des phytochromes et, en particulier, des phytochromes cyanobactériens. L'invention concerne également des procédés de génération de ces fluorophores et diverses applications de ces fluorophores.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)