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1. (WO2010138665) AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/138665    International Application No.:    PCT/US2010/036312
Publication Date: 02.12.2010 International Filing Date: 27.05.2010
IPC:
C07D 513/04 (2006.01), A61K 31/47 (2006.01), A61P 35/00 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 130 Waverly Street Cambridge, MA 02139 (US) (For All Designated States Except US).
LAUFFER, David [US/US]; (US) (For US Only).
LI, Pan [US/US]; (US) (For US Only).
McGINTY, Kira [US/US]; (US) (For US Only)
Inventors: LAUFFER, David; (US).
LI, Pan; (US).
McGINTY, Kira; (US)
Agent: PEARSON, Daniel, A.; Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge, MA 02139 (US)
Priority Data:
61/181,786 28.05.2009 US
Title (EN) AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE
(FR) INHIBITEURS À BASE DE TRIAZOLOPYRAZOLE, TRIAZOLOTHIADIAZOLE DE LA PROTÉINE KINASE C‑MET
Abstract: front page image
(EN)The present invention relates to compounds of formula (I), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula (I) and methods of using the compositions in the treatment of proliferative disorders.
(FR)La présente invention concerne des composés de formule (I) qui sont utiles dans l'inhibition de la protéine kinase c‑Met. L'invention a également pour objet des compositions pharmaceutiquement acceptables contenant des composés de formule (I) et des méthodes d'utilisation des compositions dans le traitement de troubles prolifératifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)