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Machine translation
1. (WO2010138490) BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/138490    International Application No.:    PCT/US2010/036038
Publication Date: 02.12.2010 International Filing Date: 25.05.2010
IPC:
C07D 413/04 (2006.01), C07D 413/14 (2006.01), C07D 417/14 (2006.01), C07D 471/08 (2006.01), C07D 487/08 (2006.01), C07D 519/00 (2006.01), A61K 31/553 (2006.01), A61P 35/00 (2006.01)
Applicants: EXELIXIS, INC. [US/US]; 210 East Grand Avenue P.O. Box 511 South San Francisco, CA 94083-0511 (US) (For All Designated States Except US).
AAY, Naing [US/US]; (US) (For US Only).
BLAZEY, Charles, M. [US/US]; (US) (For US Only).
BOWLES, Owen, Joseph [CA/US]; (US) (For US Only).
BUSSENIUS, Joerg [DE/US]; (US) (For US Only).
CURTIS, Jeffry, Kimo [US/US]; (US) (For US Only).
DEFINA, Steven, Charles [US/US]; (US) (For US Only).
DUBENKO, Larisa [US/US]; (US) (For US Only).
HARRIS, Jason, R. [US/US]; (US) (For US Only).
JACKSON-UGUETO, Eileen, E. [US/US]; (US) (For US Only).
KIM, Angie, Inyoung [US/US]; (US) (For US Only).
MANALO, Jean-claire, Limun [US/US]; (US) (For US Only).
PACK, Michael [US/US]; (US) (For US Only).
PETO, Csaba, J. [US/US]; (US) (For US Only).
RICE, Kenneth, D. [US/US]; (US) (For US Only).
TSANG, Tsze, H. [US/US]; (US) (For US Only).
WANG, Longcheng [CN/US]; (US) (For US Only)
Inventors: AAY, Naing; (US).
BLAZEY, Charles, M.; (US).
BOWLES, Owen, Joseph; (US).
BUSSENIUS, Joerg; (US).
CURTIS, Jeffry, Kimo; (US).
DEFINA, Steven, Charles; (US).
DUBENKO, Larisa; (US).
HARRIS, Jason, R.; (US).
JACKSON-UGUETO, Eileen, E.; (US).
KIM, Angie, Inyoung; (US).
MANALO, Jean-claire, Limun; (US).
PACK, Michael; (US).
PETO, Csaba, J.; (US).
RICE, Kenneth, D.; (US).
TSANG, Tsze, H.; (US).
WANG, Longcheng; (US)
Agent: O'BRIEN, Jonathan, P.; Honigman Miller Schwartz and Cohn LLP 350 East Michigan Avenue, Suite 300 Kalamazoo, Michigan 49007-3800 (US)
Priority Data:
61/217,145 26.05.2009 US
Title (EN) BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE
(FR) BENZOXAZÈPINES COMME INHIBITEURS DE MTOR ET MÉTHODES D'UTILISATION ET DE FABRICATION
Abstract: front page image
(EN)The invention is directed to inhibitors of mTOR and pharmaceutically acceptable salts or solvates thereof, as well as methods of using them. The inhibitors are generally of structural formula wherein the combination of R1 and R2 are as defined herein, and pharmaceutically acceptable salts thereof.
(FR)L'invention concerne des inhibiteurs de mTOR et de sels ou des solvates pharmaceutiquement acceptables de ces inhibiteurs, ainsi que leurs méthodes d'utilisation. De façon générale, ces inhibiteurs sont représentés par la formule structurelle suivante, dans laquelle R1 et R2 sont comme définis dans le descriptif.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)