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1. (WO2010138193) TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/138193    International Application No.:    PCT/US2010/001560
Publication Date: 02.12.2010 International Filing Date: 26.05.2010
IPC:
A61K 47/48 (2006.01), A61K 39/385 (2006.01), A61K 39/39 (2006.01), A61P 37/04 (2006.01), A61K 9/16 (2006.01)
Applicants: SELECTA BIOSCIENCES, INC. [US/US]; 480 Arsenal Street Building One Watertown, Massachusetts 02472 (US) (For All Designated States Except US).
ZEPP, Charles [US/US]; (US) (For US Only).
GAO, Yun [US/US]; (US) (For US Only).
KEEGAN, Mark, J. [US/US]; (US) (For US Only).
BALDWIN, Sam [US/US]; (US) (For US Only).
FU, Fen-ni [US/US]; (US) (For US Only).
JOHNSTON, Lloyd [CA/US]; (US) (For US Only).
LIPFORD, Grayson, B. [US/US]; (US) (For US Only)
Inventors: ZEPP, Charles; (US).
GAO, Yun; (US).
KEEGAN, Mark, J.; (US).
BALDWIN, Sam; (US).
FU, Fen-ni; (US).
JOHNSTON, Lloyd; (US).
LIPFORD, Grayson, B.; (US)
Agent: VATLAND, Janice A.; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210-2206 (US)
Priority Data:
61/217,129 27.05.2009 US
61/217,116 27.05.2009 US
61/217,117 27.05.2009 US
61/217,124 27.05.2009 US
Title (EN) TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS
(FR) NANOSUPPORTS DE SYNTHÈSE CIBLÉS SE CARACTÉRISANT PAR UNE LIBÉRATION SENSIBLE AU PH D'AGENTS IMMUNOMODULATEURS
Abstract: front page image
(EN)This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
(FR)La présente invention concerne des compositions, et des procédés associés, de nanosupports de synthèse qui ciblent des sites d'action dans des cellules telles que des cellules de présentation de l'antigène (CPA) et comprennent des agents immunomodulateurs qui se dissocient des nanosupports de synthèse sous l'effet de leur sensibilité au pH. L'invention a également pour objet des compositions et des procédés relatifs à des nanosupports de synthèse qui encapsulent des agents immunomodulateurs qui se dissocient des nanosupports de synthèse sous l'effet de leur sensibilité au pH.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)