WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2010137017) PROTEASOME INHIBITORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/137017    International Application No.:    PCT/IL2010/000417
Publication Date: 02.12.2010 International Filing Date: 26.05.2010
IPC:
A61K 39/00 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; at the Weizmann Institute of Science P.O. Box 95 76100 Rehovot (IL) (For All Designated States Except US).
LAVELIN, Irina [IL/IL]; (IL) (For US Only).
ROTTER, Varda [IL/IL]; (IL) (For US Only).
OREN, Moshe [IL/IL]; (IL) (For US Only).
NAVON, Ami [IL/IL]; (IL) (For US Only).
KAM, Zvi [IL/IL]; (IL) (For US Only).
GEIGER, Benjamin [IL/IL]; (IL) (For US Only)
Inventors: LAVELIN, Irina; (IL).
ROTTER, Varda; (IL).
OREN, Moshe; (IL).
NAVON, Ami; (IL).
KAM, Zvi; (IL).
GEIGER, Benjamin; (IL)
Agent: G.E EHRLICH (1995) LTD.; 11 Menachem Begin Street 52521 Ramat Gan (IL)
Priority Data:
61/213,299 27.05.2009 US
Title (EN) PROTEASOME INHIBITORS AND USES THEREOF
(FR) INHIBITEURS DES PROTÉASOMES ET LEURS UTILISATIONS
Abstract: front page image
(EN)A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.
(FR)La présente invention concerne une méthode de traitement d'une maladie dans laquelle l'inhibition d'un protéasome se révèle avantageuse. Ladite méthode comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'un composé se liant à un protéasome d'une cellule, ledit composé comprenant un cuivre lié à un ligand, ledit ligand étant conçu de façon à ce que, suite à la liaison au protéasome, le cuivre interagisse avec la cystéine 31 d'une sous-unité bêta-2 du protéasome, puis avec la cystéine 118 d'une sous-unité bêta-3 du protéasome, ce qui permet de traiter la maladie. L'invention concerne également d'autres inhibiteurs inédits des protéasomes, ainsi que des procédés d'identification des inhibiteurs des protéasomes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)