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1. (WO2010136846) Differentiation therapy for sarcomas
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/136846    International Application No.:    PCT/IB2009/052179
Publication Date: 02.12.2010 International Filing Date: 25.05.2009
C12N 15/113 (2010.01), A61K 31/7088 (2006.01), A61P 35/00 (2006.01)
Applicants: PONZETTO, Carola [IT/IT]; (IT).
TAULLI, Riccardo [IT/IT]; (IT)
Inventors: PONZETTO, Carola; (IT).
TAULLI, Riccardo; (IT)
Agent: FREYRIA FAVA, Cristina; c/o Buzzi, Notaro & Antonielli d'Oulx S.r.l. Via Maria Vittoria 18 I-10123 Turin (IT)
Priority Data:
Title (EN) Differentiation therapy for sarcomas
Abstract: front page image
(EN)Use of muscle-enriched/specific microRNAs for the treatment of sarcomas, as for example rhabdomyosarcomas, synovial sarcoma, alveolar soft part sarcoma, liposarcoma, and osteosarcoma, wherein the microRNAs are able to stop the development of neoplastic cells and to force the neoplastic cells to differentiate into terminally differentiated muscle cells.
(FR)La présente invention a pour objet l'utilisation de micro ARN musculaires enrichis / spécifiques pour le traitement des sarcomes, comme par exemple les rhabdomyosarcomes, le sarcome synovial, le sarcome alvéolaire des tissus mous, le liposarcome, et l'ostéosarcome, les micro ARN étant capables d'arrêter le développement des cellules néoplasiques et de forcer les cellules néoplasiques à se différencier en cellules musculaires à terminaisons différenciées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)