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Pub. No.:    WO/2010/136482    International Application No.:    PCT/EP2010/057229
Publication Date: 02.12.2010 International Filing Date: 26.05.2010
C07K 16/22 (2006.01), C07K 16/46 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN (GB) (For All Designated States Except US).
CLARKE, Neil James [GB/GB]; (GB) (For US Only).
FORD, Susannah Karen [GB/GB]; (GB) (For US Only).
HAMBLIN, Paul Andrew [GB/GB]; (GB) (For US Only).
MARTIN, Stephen [GB/GB]; (GB) (For US Only)
Inventors: CLARKE, Neil James; (GB).
FORD, Susannah Karen; (GB).
HAMBLIN, Paul Andrew; (GB).
MARTIN, Stephen; (GB)
Agent: HITCHCOCK, Lucy Rose; GlaxoSmithKline Global Patents CN925.1 980 Great West Road Brentford Middlesex TW8 9GS (GB)
Priority Data:
61/181,881 28.05.2009 US
Abstract: front page image
(EN)The invention relates to combinations of HGF antagonists with VEGF antagonists, and provides antigen-binding proteins which bind to HGF comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding protein has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
(FR)L'invention concerne des combinaisons d'antagonistes du HGF et d'antagonistes du VEGF, et des protéines se liant à un antigène qui se lient au HGF et comprennent un squelette de protéines liées à un ou à plusieurs domaines de liaison d'épitope. La protéine se liant à un antigène comporte au moins deux sites de liaison d'antigène, dont au moins un provient d'un domaine de liaison d'épitope et au moins provient d'un domaine VH/VL apparié. L'invention concerne des procédés de fabrication de telles protéines hybrides et des utilisations de celles-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)