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1. (WO2010135170) NITRILE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/135170 International Application No.: PCT/US2010/034838
Publication Date: 25.11.2010 International Filing Date: 14.05.2010
IPC:
A61K 31/275 (2006.01) ,A61K 31/277 (2006.01) ,C07C 335/30 (2006.01) ,C07C 335/32 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
277
having a ring, e.g. verapamil
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
335
Thioureas, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
30
Isothioureas
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
335
Thioureas, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
30
Isothioureas
32
having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
CELLCEUTIX CORPORATION [US/US]; 100 Cummings Center Suite 151-B Beverly, Massachusetts 01915, US (AllExceptUS)
MENON, Krishna [US/US]; US (UsOnly)
Inventors:
MENON, Krishna; US
Agent:
GINSBURG, Paul H.; Ostrolenk Faber LLP 1180 Avenue of the Americas New York, New York 10036, US
Priority Data:
61/180,12120.05.2009US
Title (EN) NITRILE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS
(FR) DÉRIVÉS DE NITRILE, LEUR UTILISATION ET LEURS COMPOSITIONS PHARMACEUTIQUES
Abstract:
(EN) Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I : (I) and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.
(FR) Cette invention concerne des dérivés de nitrile et des compositions pharmaceutiques comprenant des dérivés de nitrile. Les compositions pharmaceutiques comprennent des composés de formule I (I) et leurs sels pharmaceutiquement acceptables. L'invention concerne également des procédés de préparation de ces composés, des intermédiaires utilisés dans la préparation de ces composés, et les utilisations de ces composés dans le traitement des maladies hyperprolifératives, des maladies inflammatoires, des infections virales et bactériennes, et dans l'induction de l'apoptose des cellules cancéreuses.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
UAa201201041AR078509SG176170IL216462EP2432464JP2012527464
CN102438612CA2762427EA201101655JP2014240398MX2011012384KR1020120016101
KR1020140130438KR1020140147111KR1020160010888NZ596527AU2014202067AU2010249933
ID2012/00911MYPI 2011005529TH149953IN9103/DELNP/2011