Processing

Please wait...

Settings

Settings

Goto Application

1. WO2010133836 - FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS

Publication Number WO/2010/133836
Publication Date 25.11.2010
International Application No. PCT/GB2010/001000
International Filing Date 19.05.2010
IPC
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 25/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • UCB PHARMA S.A. [BE]/[BE] (AllExceptUS)
  • ALLEN, Daniel, Rees [GB]/[GB] (UsOnly)
  • BROWN, Julien, Alistair [GB]/[GB] (UsOnly)
  • BÜRLI, Roland [CH]/[GB] (UsOnly)
  • HAUGHAN, Alan, Findlay [GB]/[GB] (UsOnly)
  • LANGHAM, Barry, John [GB]/[GB] (UsOnly)
  • MATTEUCCI, Mizio [IT]/[GB] (UsOnly)
  • OWENS, Andrew, Pate [GB]/[GB] (UsOnly)
  • RAPHY, Gilles [GB]/[GB] (UsOnly)
  • SHARPE, Andrew [GB]/[GB] (UsOnly)
Inventors
  • ALLEN, Daniel, Rees
  • BROWN, Julien, Alistair
  • BÜRLI, Roland
  • HAUGHAN, Alan, Findlay
  • LANGHAM, Barry, John
  • MATTEUCCI, Mizio
  • OWENS, Andrew, Pate
  • RAPHY, Gilles
  • SHARPE, Andrew
Agents
  • THOMPSON, John
Priority Data
0908957.422.05.2009GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS BICYCLIQUES FUSIONNÉS DE PYRAZOLE CONVENANT COMME INHIBITEURS DE KINASES
Abstract
(EN) A series of substituted pyrazolo[l,5-α][l,3,5]triazine and pyrazolo[l,5-αj- pyrimidine derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. Formula (I).
(FR) La présente invention concerne une série de dérivés substitués de pyrazolo[l,5-α][l,3,5]triazine et de pyrazolo[l,5-αj-pyrimidine qui sont des inhibiteurs sélectifs des kinases PI3. Ces dérivés intéressent donc la médecine, notamment pour le traitement d'états inflammatoires, auto-immuns, cardiovasculaires, neurodégénératifs, métaboliques, oncologiques, nociceptifs, ou ophtalmiques.
Related patent documents
Latest bibliographic data on file with the International Bureau