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1. WO2010132886 - COMPOSITIONS AND METHODS RELATING TO XMRV-RELATED DISEASES AND CONDITIONS

Publication Number WO/2010/132886
Publication Date 18.11.2010
International Application No. PCT/US2010/035144
International Filing Date 17.05.2010
IPC
C12Q 1/04 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12N 7/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
C07K 16/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
G01N 33/53 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
A61K 31/5025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
A61K 9/0056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
A61K 9/2068
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2068Compounds of unknown constitution, e.g. material from plants or animals
C07K 16/1036
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
1036Retroviridae, e.g. leukemia viruses
C07K 16/3069
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
3069Reproductive system, e.g. ovaria, uterus, testes, prostate
C12N 2740/13022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2740Reverse Transcribing RNA Viruses
00011Reverse Transcribing RNA Viruses
10011Retroviridae
13011Gammaretrovirus, e.g. murine leukeamia virus
13022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applicants
  • THE UNIVERSITY OF UTAH RESEARCH FOUNDATION [US]/[US] (AllExceptUS)
  • SINGH, Ila Ramnaresh [US]/[US] (UsOnly)
  • THAKER, Harshwardhan Manohar [US]/[US] (UsOnly)
  • SCHLABERG, Robert [DE]/[US] (UsOnly)
  • SHIN, Clifford [US]/[US] (UsOnly)
Inventors
  • SINGH, Ila Ramnaresh
  • THAKER, Harshwardhan Manohar
  • SCHLABERG, Robert
  • SHIN, Clifford
Agents
  • MEARA, Joseph P.
Priority Data
61/216,31715.05.2009US
61/239,22002.09.2009US
61/247,90301.10.2009US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS RELATING TO XMRV-RELATED DISEASES AND CONDITIONS
(FR) COMPOSITIONS ET MÉTHODES APPLIQUÉES À DES MALADIES ET DES TROUBLES ASSOCIÉS À XMRV
Abstract
(EN) Disclosed herein are methods and compositions relating to the diagnosis of XMRV infection and XMRV-related diseases, including but not limited to malignancies such as prostate cancer, lymphomas, leukemias, myelodysplastic diseases, thymomas and also non-cancerous conditions such as chronic fatigue syndrome, and other neuroimmune disorders. The methods involve detection of XMRV RNA or DNA, or XMRV proteins, or antibodies to XMRV, and the use of these methods for diagnosis, for monitoring the progression of disease, and in monitoring treatment efficacy of various XMRV-associated diseases. Also disclosed herein are methods and compositions relating to the assessment of the cancer grade and long-term prognosis of a subject with cancer through the detection of anti-XMRV antibodies.
(FR) L'invention porte sur des méthodes et des compositions appliquées au diagnostic d'une infection par XMRV et des maladies associées à XMRV, comprenant mais sans y être limité des tumeurs malignes telles qu'un cancer de la prostate, des lymphomes, des leucémies, des maladies myélodysplasiques, des thymomes et également des troubles non cancéreux tels qu'un syndrome de fatigue chronique et autres troubles neuroimunologiques. Les méthodes mettent en jeu la détection d'ARN ou d'ADN de XMRV ou de protéines de XMRV, ou d'anticorps dirigés contre XMRV. L'invention porte également sur l'utilisation de ces méthodes pour diagnostiquer, surveiller la progression d'une maladie et l'efficacité thérapeutique de diverses maladies associées à XMRV. L'invention porte également sur des méthodes et des compositions appliquées à l'évaluation du stade d'un cancer et au pronostic à long terme d'un sujet atteint d'un cancer par détection d'anticorps anti-XMRV.
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