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1. (WO2010132562) TRANSDERMAL DELIVERY OF METFORMIN
PCT Biblio. Data
Description
Claims
National Phase
Notices
Documents
Latest bibliographic data on file with the International Bureau
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Pub. No.:
WO/2010/132562
International Application No.:
PCT/US2010/034542
Publication Date:
18.11.2010
International Filing Date:
12.05.2010
IPC:
A61K 9/06
(2006.01) ,
A61K 9/107
(2006.01) ,
A61K 31/155
(2006.01) ,
A61P 3/10
(2006.01) ,
A61P 3/00
(2006.01)
A
HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A
HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A
HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (
), e.g. guanidine (H
2
N-C(
NH)-NH
2
), isourea (HN
C(OH)NH
2
), isothiourea (HN
C(SH)-NH
2
)
A
HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A
HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
Applicants:
SCARBROUGH, Chase, A.
[US/US]; US (UsOnly)
SCARBROUGH, Stanley, S.
[US/US]; US (UsOnly)
SHUBROOK, Jay
[US/US]; US (UsOnly)
OHIO UNIVERSITY
; Technology Transfer Office 340 West State Street, Unit 14 Athens, OH 45710, US (AllExceptUS)
Inventors:
SCARBROUGH, Chase, A.
; US
SCARBROUGH, Stanley, S.
; US
SHUBROOK, Jay
; US
Agent:
DOBREA, Diane, H.
; Dinsmore & Shohl LLP 191 W. Nationwide Blvd., Suite 300 Columbus, OH 43215, US
Priority Data:
61/177,625
12.05.2009
US
Title
(EN)
TRANSDERMAL DELIVERY OF METFORMIN
(FR)
ADMINISTRATION TRANSDERMIQUE DE METFORMINE
Abstract:
(EN)
Transdermal metformin is an effective alternative treatment modality in patients with insulin resistance who are unable to tolerate other oral anti-diabetic medications. Transdermal metformin can be used in conditions where oral metformin is indicated such as Type 2 diabetes mellitus, pre-diabetes, polycystic ovarian syndrome, and other known diabetes associated disorders. One advantage of using transdermal metformin is its ability to bypass the gastrointestinal system. This allows the drug to not have the gastrointestinal side-effects associated with oral metformin. A surprising advantage of using transdermal metformin in accordance with this disclosure is a 90% decrease in dosage from the oral preparation.
(FR)
La présente invention concerne la metformine par voie transdermique comme modalité de traitement alternative efficace chez les patients atteints de résistance à l'insuline qui sont incapables de tolérer d'autres médicaments antidiabétiques. La metformine par voie transdermique peut être utilisée dans des conditions dans lesquelles la metformine par voie orale est indiquée, comme le diabète sucré de type 2, le prédiabète, le syndrome des ovaires polykystiques, et autres troubles associés au diabète. Un avantage d'utiliser la metformine par voie transdermique est son aptitude à contourner le système gastro-intestinal. Ceci permet d'éviter les effets secondaires gastro-intestinaux associés à la metformine par voie orale. Un avantage surprenant de l'utilisation de la metformine par voie transdermique selon la présente invention est une diminution de 90 % de la posologie par rapport à la préparation par voie orale.
Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language:
English (
EN
)
Filing Language:
English (
EN
)