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1. (WO2010129959) COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF LUPUS NEPHRITIS USING ANTI-DSDNA GERMLINE ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/129959 International Application No.: PCT/US2010/034257
Publication Date: 11.11.2010 International Filing Date: 10.05.2010
IPC:
C07K 16/06 (2006.01) ,C07K 16/44 (2006.01) ,G01N 33/564 (2006.01) ,A61K 39/395 (2006.01) ,A61P 37/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
06
from serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
44
against material not provided for elsewhere
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
564
for pre-existing immune complex or autoimmune disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
Applicants:
GOVERNMENT OF THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer 6011 Executive Boulevard, Suite 325 Rockville, MD 20852-3804, US (AllExceptUS)
DIAZ, Marilyn [US/US]; US (UsOnly)
JIANG, Chuancang [US/US]; US (UsOnly)
ZHAO, Ming, Lang [US/US]; US (UsOnly)
Inventors:
DIAZ, Marilyn; US
JIANG, Chuancang; US
ZHAO, Ming, Lang; US
Agent:
CORLESS, Peter F.; Edwards Angell Palmer & Dodge LLP P.O. Box 55874 Boston, MA 02205, US
Priority Data:
61/176,61508.05.2009US
Title (EN) COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF LUPUS NEPHRITIS USING ANTI-DSDNA GERMLINE ANTIBODIES
(FR) COMPOSITIONS ET PROCÉDÉS POUR LA PRÉVENTION ET LE TRAITEMENT DU LUPUS NÉPHRÉTIQUE À L'AIDE D'ANTICORPS DE LIGNÉE GERMINALE ANTI-ADN DOUBLE BRIN
Abstract:
(EN) The invention provides IgM germline anti-dsDNA antibodies and their use in the prevention, amelioration, and treatment of lupus nephritis. As demonstrated herein, germline IgM antibodies that bind specifically to dsDNA were demonstrated to have a protective effect in preventing or ameliorating the development of lupus nephritis in the MRL/lpr mouse model of lupus. The effect was demonstrated to be specific to germline IgM antibodies rather than hypermutated antibodies, and further to antibodies with dsDNA antigen specificity.
(FR) L'invention porte sur des anticorps anti-ADN double brin de lignée germinale IgM et sur leur utilisation dans la prévention, l'amélioration et le traitement d'un lupus néphrétique. Comme démontré ici, les anticorps IgM de lignée germinale qui se lient spécifiquement à de l'ADN double brin ont été démontrés avoir un effet protecteur dans la prévention ou l'amélioration du développement d'un lupus néphrétique dans le modèle souris MLR/lpr de lupus. L'effet a été démontré être spécifique à des anticorps IgM de lignée germinale plutôt qu'à des anticorps hypermutés, et davantage à des anticorps avec une spécificité antigénique pour l'ADN double brin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)