Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2010129692) COMPOSITE TISSUE-ENGINEERED INTERVERTEBRAL DISC WITH SELF-ASSEMBLED ANNULAR ALIGNMENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/129692 International Application No.: PCT/US2010/033752
Publication Date: 11.11.2010 International Filing Date: 05.05.2010
IPC:
A61F 2/44 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02
Prostheses implantable into the body
30
Joints
44
for the spine, e.g. vertebrae, spinal discs
Applicants:
CORNELL UNIVERSITY [US/US]; Cornell Center Of Technology Enterprise & Commercialization 395 Pine Tree Road, Suite 310 Ithaca, NY 14850, US (AllExceptUS)
BONASSAR, Lawrence, J. [US/US]; US (UsOnly)
HARTL, Roger [DE/US]; US (UsOnly)
BOWLES, Robert, D. [US/US]; US (UsOnly)
GEBHARD, Harry, H. [DE/US]; US (UsOnly)
Inventors:
BONASSAR, Lawrence, J.; US
HARTL, Roger; US
BOWLES, Robert, D.; US
GEBHARD, Harry, H.; US
Agent:
TISCHNER, Tate, L.; LeClairRyan 290 Linden Oaks, Suite 310 Rochester, NY 14625, US
Priority Data:
61/175,68005.05.2009US
Title (EN) COMPOSITE TISSUE-ENGINEERED INTERVERTEBRAL DISC WITH SELF-ASSEMBLED ANNULAR ALIGNMENT
(FR) DISQUE INTERVERTÉBRAL À TISSU COMPOSITE ET ALIGNEMENT ANNULAIRE AUTO-ASSEMBLÉ
Abstract:
(EN) The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell- mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
(FR) La présente invention concerne un disque intervertébral (IVD) à tissu qui convient pour le remplacement total de disques chez un mammifère, et des procédés pour sa fabrication. L'IVD comprend une structure de noyau pulpeux qui comprend une première population de cellules vivantes qui sécrètent une protéine hydrophile et une structure d'anneau fibreux qui entoure la structure de noyau pulpeux et en contact avec elle, la structure d'anneau fibreux comprenant une deuxième population de cellules vivantes et du collagène de type I. Les fibrilles de collagène de la structure d'anneau fibreux sont alignées périphériquement autour de la partie formant le noyau pulpeux grâce à la contraction médiée par les cellules de la structure d'anneau fibreux. L'invention concerne également des procédés de fabrication de disques intervertébraux à tissu.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20130079881