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1. (WO2010129681) METHODS FOR TREATING AUTOPHAGY-RELATED DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/129681 International Application No.: PCT/US2010/033740
Publication Date: 11.11.2010 International Filing Date: 05.05.2010
IPC:
C07H 21/04 (2006.01) ,A61K 31/415 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
Applicants:
VAN ANDEL RESEARCH INSTITUTE [US/US]; 333 Bostwick Avenue, N.E. Grand Rapids, Michigan 49503, US (AllExceptUS)
MACKEIGAN, Jeffrey Paul [US/US]; US (UsOnly)
MARTIN, Katie R. [US/US]; US (UsOnly)
XU, Huaqiang Eric [US/US]; US (UsOnly)
XU, Yong [CN/US]; US (UsOnly)
Inventors:
MACKEIGAN, Jeffrey Paul; US
MARTIN, Katie R.; US
XU, Huaqiang Eric; US
XU, Yong; US
Agent:
SIEGEL, Douglas, H.; Honigman Miller Schwartz and Cohn LLP 350 East Michigan Avenue, Suite 300 Kalamazoo, MI 49007-3800, US
Priority Data:
61/175,65705.05.2009US
Title (EN) METHODS FOR TREATING AUTOPHAGY-RELATED DISORDERS
(FR) MÉTHODES DE TRAITEMENT DE TROUBLES LIÉS À L'AUTOPHAGIE
Abstract:
(EN) Methods for treating autophagy-related disorders with agents which modulate expression of the gene encoding tyrosine phosphatase receptor type sigma (PTPRS) or which modulate the biological activity of the PTPRS gene product (PTPsigma). Methods for modulating autophagy in a cell with agents which modulate expression of PTPRS or which modulate the biological activity of PTPsigma; and related diagnostic methods, screening methods, and agents.
(FR) L'invention porte sur des méthodes de traitement de troubles liés à l'autophagie par des agents qui modulent l'expression du gène codant pour le récepteur de la tyrosine phosphatase de type sigma (PTPRS) ou qui modulent l'activité biologique du produit de gène PTPRS (PTPsigma). L'invention porte également sur des procédés destinés à moduler l'autophagie dans une cellule par des agents qui modulent l'expression de PTPRS ou qui modulent l'activité biologique de PTPsigma ; et sur des méthodes de diagnostic, des procédés de criblage et des agents apparentés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20120045459