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1. (WO2010128977) INTRAVENOUS FORMULATION WITH WATER-SOLUBLE COCRYSTALS OF ACETYLSALICYLIC ACID AND THEANINE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/128977 International Application No.: PCT/US2009/048275
Publication Date: 11.11.2010 International Filing Date: 23.06.2009
IPC:
A61K 31/60 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
60
Salicylic acid; Derivatives thereof
Applicants:
SOLUPRIN PHARMACEUTICALS, INC. [US/US]; 100 Park Avenue, Suite 1600 New York, NY 10017, US (AllExceptUS)
BRITTAIN, Harry, G. [US/US]; US (UsOnly)
FELICE, Philip, V. [US/US]; US (UsOnly)
Inventors:
BRITTAIN, Harry, G.; US
FELICE, Philip, V.; US
Agent:
MICHALOS, Peter, C.; Notaro & Michalos P.C. 100 Dutch Hill Road, Suite 110 Orangeburg, NY 10962-2100, US
Priority Data:
12/437,73508.05.2009US
Title (EN) INTRAVENOUS FORMULATION WITH WATER-SOLUBLE COCRYSTALS OF ACETYLSALICYLIC ACID AND THEANINE
(FR) FORMULATION INTRAVEINEUSE AVEC DES COCRISTAUX HYDROSOLUBLES D'ACIDE ACÉTYLSALICYLIQUE ET DE THÉANINE
Abstract:
(EN) A water-soluble aspirin-theanine cocrystal composition which includes a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer associated with the quantity of acetylsalicylic acid. The composition may be created by a method including the steps of : (i) providing a quantity of acetylsalicylic acid; (ii) adding a quantity of a theanine enantiomer to the quantity of acetylsalicylic acid to form a mixture comprising the quantity of acetylsalicylic acid and the enantiomer of theanine; (iii) wetting the mixture; and (iv) grinding the mixture for a length of time sufficient to produce a dried crystalline mass. The water-soluble cocrystal composition is suitable for intravenous administration, preferably to humans.
(FR) La présente invention concerne une composition de cocristal aspirine-théanine hydrosoluble qui comprend une quantité d'acide acétylsalicylique et une quantité d'un énantiomère de théanine associée à la quantité d'acide acétylsalicylique. La composition peut être créée par un procédé comprenant les étapes de : (i) fourniture d'une quantité d'acide acétylsalicylique ; (ii) ajout d'une quantité d'un énantiomère de théanine à la quantité d'acide acétylsalicylique pour former un mélange comprenant la quantité d'acide acétylsalicylique et l'énantiomère de théanine ; (iii) mouillage du mélange ; et (iv) broyage du mélange pendant une durée suffisante pour produire une masse cristalline séchée. La composition de cocristal hydrosoluble est adaptée pour administration intraveineuse, de préférence à des humains.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
SG175921IL215922EP2427196JP2012526105CN102421438CA2760555
EA201101458MX2011011871KR1020120011031NZ596200AU2009345832AU2013201664
IN3937/KOLNP/2011