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1. (WO2010128443) PYRROLIDINE-SUBSTITUTED FLAVONES AS RADIO-SENSITIZERS FOR USE IN THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/128443 International Application No.: PCT/IB2010/051921
Publication Date: 11.11.2010 International Filing Date: 03.05.2010
IPC:
A61K 31/4025 (2006.01) ,A61K 31/00 (2006.01) ,A61P 35/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025
not condensed and containing further heterocyclic rings, e.g. cromakalim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
PIRAMAL LIFE SCIENCES LIMITED [IN/IN]; Piramal Tower Ganpatrao Kadam Marg Lower Parel Mumbai 400 013, IN (AllExceptUS)
RATHOS, Maggie Joyce [IN/IN]; IN (UsOnly)
JOSHI, Kalpana Sanjay [IN/IN]; IN (UsOnly)
HEBBAR, Nikhil Krishnamurthy [IN/IN]; IN (UsOnly)
SHARMA, Somesh [US/IN]; IN (UsOnly)
Inventors:
RATHOS, Maggie Joyce; IN
JOSHI, Kalpana Sanjay; IN
HEBBAR, Nikhil Krishnamurthy; IN
SHARMA, Somesh; IN
Priority Data:
1174/MUM/2009 05.05.2009IN
61/224,52410.07.2009US
Title (EN) PYRROLIDINE-SUBSTITUTED FLAVONES AS RADIO-SENSITIZERS FOR USE IN THE TREATMENT OF CANCER
(FR) FLAVONES À SUBSTITUTION PYRROLIDINE EN TANT QUE RADIOSENSIBILISEURS À UTILISER DANS LE TRAITEMENT DU CANCER
Abstract:
(EN) The present invention relates to a combination for the treatment of cancer wherein the combination exhibits a synergistic effect. The combination comprises radiation and at least one cyclin dependent kinase (CDK) inhibitor selected from the compounds of formula I or a pharmaceutically acceptable salt or a solvate thereof. The present invention also relates to a method for the treatment of cancer, which method comprises administering to a patient in need of such a treatment, a therapeutically effective amount of the combination. The present invention also relates to the use of a CDK inhibitor selected from the compounds of formula I as a radiosensitizer that enhances the efficacy of radiotherapy for the treatment of cancer, particularly head and neck cancer.
(FR) La présente invention concerne une combinaison destinée au traitement du cancer, la combinaison présentant un effet synergique. La combinaison comprend des radiations et au moins un inhibiteur de kinase cycline-dépendante (CDK) choisi parmi les composés de formule I ou l'un de leurs sels pharmaceutiquement acceptables ou solvates. La présente invention a également pour objet une méthode de traitement du cancer, laquelle méthode comprend l'administration à un patient ayant besoin d'un tel traitement, d'une quantité thérapeutiquement efficace de la combinaison. La présente invention concerne également l'utilisation d'un inhibiteur de CDK choisi parmi les composés de formule I en tant que radiosensibiliseur qui amplifie l'efficacité de la radiothérapie pour le traitement du cancer, particulièrement le cancer de la tête et du cou.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL216163EP2427188US20120046334JP2012526098CN102458398RU2011148954
CA2761182KR1020120032476NZ596861AU2010244101IN2599/MUMNP/2011BRPI1015545