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1. WO2010128414 - GPR 119 MODULATORS

Publication Number WO/2010/128414
Publication Date 11.11.2010
International Application No. PCT/IB2010/051567
International Filing Date 12.04.2010
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
08
Bridged systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
497
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
C07D 401/14 (2006.01)
C07D 471/04 (2006.01)
C07D 491/08 (2006.01)
A61K 31/497 (2006.01)
A61P 3/10 (2006.01)
CPC
C07D 401/14
C07D 471/04
C07D 491/08
Applicants
  • PFIZER INC. [US/US]; 235 East 42nd Street New York, New York 10017, US (AllExceptUS)
  • DAROUT, Etzer [US/US]; US (UsOnly)
  • DENINNO, Michael, Paul [US/US]; US (UsOnly)
  • FUTATSUGI, Kentaro [JP/US]; US (UsOnly)
  • GUIMARAES, Cristiano, Ruch, Werneck [BR/US]; US (UsOnly)
  • LEFKER, Bruce, Allen [US/US]; US (UsOnly)
  • MASCITTI, Vincent [FR/US]; US (UsOnly)
  • MCCLURE, Kim, Francis [US/US]; US (UsOnly)
  • MUNCHHOF, Michael, John [US/US]; US (UsOnly)
  • ROBINSON, Ralph, Pelton, Jr. [US/US]; US (UsOnly)
Inventors
  • DAROUT, Etzer; US
  • DENINNO, Michael, Paul; US
  • FUTATSUGI, Kentaro; US
  • GUIMARAES, Cristiano, Ruch, Werneck; US
  • LEFKER, Bruce, Allen; US
  • MASCITTI, Vincent; US
  • MCCLURE, Kim, Francis; US
  • MUNCHHOF, Michael, John; US
  • ROBINSON, Ralph, Pelton, Jr.; US
Agents
  • KLEIMAN, Gabriel, L.; Pfizer Inc. 235 East 42 Street New York, New York 10017, US
Priority Data
61/176,52808.05.2009US
61/320,46202.04.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GPR 119 MODULATORS
(FR) MODULATEURS DU GPR119
Abstract
(EN)
Compounds of Formula (I) that modulate the activity of the G -protein-coupled receptor GPFM 19 and their uses in the treatment of diseases linked to the modulation of the G-protein-coupled receptor GPR119 in animals are described herein.
(FR)
La présente invention concerne des composés représentés par la formule (I) modulant l'activité du récepteur couplé à la protéine G GPR119 ainsi que leurs utilisations dans le traitement de maladies liées à la modulation du récepteur couplé à la protéine G GPR119 chez les animaux.
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