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1. (WO2010125572) COMPRESSED TABLETS AND CAPSULES CONTAINING EFAVIRENZ
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/125572 International Application No.: PCT/IN2009/000259
Publication Date: 04.11.2010 International Filing Date: 29.04.2009
IPC:
A61K 31/536 (2006.01) ,A61K 47/32 (2006.01) ,A61K 47/36 (2006.01) ,A61K 47/38 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
536
ortho- or peri-condensed with carbocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
32
Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
Applicants:
HETERO RESEARCH FOUNDATION [IN/IN]; Plot No. B-80 & 81, A.P.I.E., Balanagar, Hyderabad, Andhrapradesh Hyderabad 500018, IN (AllExceptUS)
PARTHASARADHI REDDY, Bandi [IN/IN]; IN (UsOnly)
KHADGAPATHI, Podili [IN/IN]; IN (UsOnly)
KAMALAKAR REDDY, Goli [IN/IN]; IN (UsOnly)
VAMSI KIRAN, Atluri [IN/IN]; IN (UsOnly)
VAMSHI KRISHNA, Lekkala [IN/IN]; IN (UsOnly)
SUDHAKAR, Pulakonda [IN/IN]; IN (UsOnly)
Inventors:
PARTHASARADHI REDDY, Bandi; IN
KHADGAPATHI, Podili; IN
KAMALAKAR REDDY, Goli; IN
VAMSI KIRAN, Atluri; IN
VAMSHI KRISHNA, Lekkala; IN
SUDHAKAR, Pulakonda; IN
Priority Data:
Title (EN) COMPRESSED TABLETS AND CAPSULES CONTAINING EFAVIRENZ
(FR) COMPRIMÉS ET CAPSULES CONTENANT DE L'ÉFAVIRENZ
Abstract:
(EN) The present invention provides improved oral dosage form formulations of efavirenz useful in the prevention or treatment of infection by HIV and the process for preparing them. Thus, for example the improved oral dosage form of efavirenz which is prepared by wet granulating efavirenz, a disintegrant and other excipients in the presence of aqueous solution of sodium lauryl sulfate, drying the granules at a temperature of about 25°C to 45°C, dry blending, lubricating with pharmaceutically acceptable ingredients and compressed into tablets or filled in capsules.
(FR) Cette invention concerne des préparations orales d'éfavirenz améliorées utilisées dans la prévention ou le traitement de l'infection par le VIH et leur procédé de fabrication. La préparation orale d'éfavirenz améliorée peut, par exemple, être fabriquée en réduisant sous forme de granulés et en milieu humide l'éfavirenz, un délitant et d'autres excipients en présence d'une solution aqueuse de laurylsulfate de sodium, en séchant les granulés à une température d'environ 25 °C à 45 °C, en mélangeant à sec, en lubrifiant avec des ingrédients pharmaceutiquement acceptables, et en comprimant la préparation obtenue sous forme de pastilles ou en l'introduisant dans des capsules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IN7687/CHENP/2011