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1. (WO2010124283) METHODS AND COMPOSITIONS RELATING TO HEMATOLOGIC MALIGNANCIES

Pub. No.:    WO/2010/124283    International Application No.:    PCT/US2010/032416
Publication Date: Fri Oct 29 01:59:59 CEST 2010 International Filing Date: Tue Apr 27 01:59:59 CEST 2010
IPC: A61K 31/38
A61K 31/415
A61K 31/65
A61P 19/08
A61P 35/00
Applicants: THE JACKSON LABORATORY
LI, Shaoguang
Inventors: LI, Shaoguang
Title: METHODS AND COMPOSITIONS RELATING TO HEMATOLOGIC MALIGNANCIES
Abstract:
Methods of treating a subject having, or at risk of having, a myeloproliferative disorder are provided according to embodiments of the present invention which include administering a therapeutically effective amount of an arachidonate 5- lipoxygenase (5-LO) inhibitor to the subject. Combinations of therapeutic agents are administered according to embodiments of the present invention. In some embodiments, two or more 5-LO inhibitors are administered to a subject to treat a myeloproliferative disorder. In further embodiments, at least one 5-LO inhibitor and at least one additional therapeutic agent are administered to a subject to treat a myeloproliferative disorder. Methods of inhibiting leukemia stem cells are provided according to embodiments of the present invention which include contacting leukemia stem cells with an effective amount of an arachidonate 5-lipoxygenase inhibitor.