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1. (WO2010124240) BIN1 AS A PROGNOSTIC MARKER IN CARDIOVASCULAR DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/124240 International Application No.: PCT/US2010/032282
Publication Date: 28.10.2010 International Filing Date: 23.04.2010
IPC:
C12Q 1/68 (2006.01) ,C12N 15/12 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants: SHAW, Robin[US/US]; US (UsOnly)
HONG, Ting-Ting[CN/US]; US (UsOnly)
SMYTH, James[IE/US]; US (UsOnly)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA[US/US]; 1111 Franklin Street Twelfth Floor Oakland, CA 94607, US (AllExceptUS)
Inventors: SHAW, Robin; US
HONG, Ting-Ting; US
SMYTH, James; US
Agent: FRANCIS, Carol, L.; 1900 University Avenue Suite 200 East Palo Alto, CA 94303, US
Priority Data:
61/172,60824.04.2009US
Title (EN) BIN1 AS A PROGNOSTIC MARKER IN CARDIOVASCULAR DISEASE
(FR) BIN1 COMME MARQUEUR DE PRONOSTIC DANS UNE MALADIE CARDIOVASCULAIRE
Abstract:
(EN) The present disclosure provides methods involving use of BIN1 expression levels, in heart tissue, in evaluating the risk of cardiac mortality in a patient diagnosed with congestive heart failure. The methods finds use in evaluating patients who are heart transplant candidates, as well as in assessing efficacy of treatment in congestive heart failure patients.
(FR) La présente invention se rapporte à des procédés impliquant l'utilisation de niveaux d'expression de BIN1 dans des tissus cardiaques pour évaluer le risque de mortalité cardiaque d'un patient diagnostiqué comme présentant une insuffisance cardiaque congestive. Les procédés trouvent leur utilisation dans l'évaluation des patients candidats à une transplantation cardiaque ainsi que dans l'évaluation de l'efficacité du traitement des patients présentant une insuffisance cardiaque congestive.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)