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1. (WO2010124227) METHODS AND DEVICES FOR CAPTURING CIRCULATING TUMOR CELLS

Pub. No.:    WO/2010/124227    International Application No.:    PCT/US2010/032266
Publication Date: Fri Oct 29 01:59:59 CEST 2010 International Filing Date: Sat Apr 24 01:59:59 CEST 2010
IPC: G01N 33/574
G01N 33/68
C12N 5/09
Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
HONG, Seungpyo
EDDINGTON, David
MYUNG, Ja Hye
LAUNIERE, Cari
Inventors: HONG, Seungpyo
EDDINGTON, David
MYUNG, Ja Hye
LAUNIERE, Cari
Title: METHODS AND DEVICES FOR CAPTURING CIRCULATING TUMOR CELLS
Abstract:
A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The flow modification surface induces a rotational flow within the sample as it flows through the microfluidic device.